Metabolic profiling studies on the toxicological effects of realgar in rats by H-1 NMR spectroscopy
文献类型：期刊论文
| 作者 | Wei L ; Liao PQ ; Wu HF ; Li XJ ; Pei FK ; Li WS ; Wu YJ |
| 刊名 | toxicology and applied pharmacology
 |
| 出版日期 | 2009 |
| 卷号 | 234期号:3页码:314-325 |
| 关键词 | ACUTE PROMYELOCYTIC LEUKEMIA ARSENIC TRIOXIDE AS2O3 MAGNETIC-RESONANCE SPECTROSCOPY NMR-SPECTROSCOPY INDUCED HEPATOTOXICITY PATTERN-RECOGNITION METABONOMICS PLASMA URINE CELLS |
| ISSN号 | 0041-008x |
| 通讯作者 | li xj |
| 中文摘要 | the toxicological effects of realgar after intragastrical administration (1 g/kg body weight) were investigated over a 21 day period in male wistar rats using metabonomic analysis of h-1 nmr spectra of urine, serum and liver tissue aqueous extracts. liver and kidney histopathology examination and serum clinical chemistry analyses were also performed. h-1 nmr spectra and pattern recognition analyses from realgar treated animals showed increased excretion of urinary kreb's cycle intermediates, increased levels of ketone bodies in urine and serum, and decreased levels of hepatic glucose and glycogen, as well as hypoglycemia and hyperlipoidemia, suggesting the perturbation of energy metabolism. elevated levels of choline containing metabolites and betaine in serum and liver tissue aqueous extracts and increased serum creatine indicated altered transmethylation. decreased urinary levels of trimethylamine-n-oxide, phenylacetylglycine and hippurate suggested the effects on the gut microflora environment by realgar. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000263253700006 |
| 公开日期 | 2010-06-18 |
| 源URL | [http://202.98.16.49/handle/322003/12653]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wei L,Liao PQ,Wu HF,et al. Metabolic profiling studies on the toxicological effects of realgar in rats by H-1 NMR spectroscopy[J]. toxicology and applied pharmacology,2009,234(3):314-325. |
| APA | Wei L.,Liao PQ.,Wu HF.,Li XJ.,Pei FK.,...&Wu YJ.(2009).Metabolic profiling studies on the toxicological effects of realgar in rats by H-1 NMR spectroscopy.toxicology and applied pharmacology,234(3),314-325. |
| MLA | Wei L,et al."Metabolic profiling studies on the toxicological effects of realgar in rats by H-1 NMR spectroscopy".toxicology and applied pharmacology 234.3(2009):314-325. |
入库方式： OAI收割
来源：长春应用化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。