Biochemical effects of gadolinium chloride in rats liver and kidney studied by H-1 NMR metabolomics
文献类型：期刊论文
| 作者 | Liao PQ ; Wei L ; Wu HF ; Li WS ; Wu YJ ; Li XJ ; Ni JZ ; Pei FK |
| 刊名 | journal of rare earths
 |
| 出版日期 | 2009 |
| 卷号 | 27期号:2页码:280-287 |
| ISSN号 | 1002-0721 |
| 关键词 | MAGNETIC-RESONANCE-SPECTROSCOPY PATTERN-RECOGNITION NMR-SPECTROSCOPY ALPHA-NAPHTHYLISOTHIOCYANATE TOXICITY URINE METABONOMICS EXTRACTION TISSUES PLASMA |
| 通讯作者 | pei fk |
| 中文摘要 | the biochemical effects of gadolinium chloride were studied using high-resolution h-1 nuclear magnetic resonance (nmr) spectroscopy to investigate the biochemical composition of tissue (liver and kidney) aqueous extracts obtained from control and gadolinium chloride (gdcl3) (10 and 50 mg/kg body weight, intraperitoneal injection. i.p.) treated rats. tissue samples were collected at 48, 96 and 168 h p.d. after exposure to gdcl3, and extracted using methanol/chloroform solvent system. h-1 nmr spectra of tissue extracts were analyzed by pattern recognition using principal components analysis. the liver damages caused by gdcl3 were characterized by increased succinate and decreased glycogen level and elevated lactate, alanine and betaine concentration in liver. furthermore, the increase of creatine and lactate, and decrease of glutamate, alanine, phosphocholine, glycophosphocholine (gpc), betaine, myo-inositol and trimethylamine n-oxide (tmao) levels in kidney illustrated kidney disturbance induced by gdcl3. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000266020900020 |
| 公开日期 | 2010-06-18 |
| 源URL | [http://202.98.16.49/handle/322003/12675]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Liao PQ,Wei L,Wu HF,et al. Biochemical effects of gadolinium chloride in rats liver and kidney studied by H-1 NMR metabolomics[J]. journal of rare earths,2009,27(2):280-287. |
| APA | Liao PQ.,Wei L.,Wu HF.,Li WS.,Wu YJ.,...&Pei FK.(2009).Biochemical effects of gadolinium chloride in rats liver and kidney studied by H-1 NMR metabolomics.journal of rare earths,27(2),280-287. |
| MLA | Liao PQ,et al."Biochemical effects of gadolinium chloride in rats liver and kidney studied by H-1 NMR metabolomics".journal of rare earths 27.2(2009):280-287. |
入库方式： OAI收割
来源：长春应用化学研究所
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