7-Amino actinomycin D bound to single-stranded hairpin DNA enhanced by loop sequence-dependent luminescent Eu3+ and Tb3+ binding
文献类型：期刊论文
| 作者 | Peng YH ; Song YJ ; Feng LY ; Ren JS ; Qu XG |
| 刊名 | journal of inorganic biochemistry
 |
| 出版日期 | 2009 |
| 卷号 | 103期号:12页码:1675-1679 |
| 关键词 | GUANINE-CONTAINING OLIGOMERS LANTHANIDE ION LUMINESCENCE AMINO ACID COMPLEXES REVERSE-TRANSCRIPTASE PROBE NUCLEOTIDES RESIDUES EUROPIUM |
| ISSN号 | 0162-0134 |
| 通讯作者 | qu xg |
| 中文摘要 | lanthanide eu3+ and tb3+ ions have been widely used in luminescent resonance energy transfer (lret) for bioassays to study metal binding microenvironments. we report here that eu3+ or tb3+ can increase the binding affinity of antitumor antibiotic drug agent, 7-amino actinomycin d (7aactd), binding to 5'-gt/tg-5' or 5'-ga/ag-5' mismatched stem region of the single-stranded hairpin dna. further studies indicate that the effect of eu3+ or tb3+ on 7aactd binding is related to dna loop sequence. our results will provide new insights into how metal ions can enhance antitumor agents binding to their targets. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000271837800011 |
| 公开日期 | 2010-06-18 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/12717]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Peng YH,Song YJ,Feng LY,et al. 7-Amino actinomycin D bound to single-stranded hairpin DNA enhanced by loop sequence-dependent luminescent Eu3+ and Tb3+ binding[J]. journal of inorganic biochemistry,2009,103(12):1675-1679. |
| APA | Peng YH,Song YJ,Feng LY,Ren JS,&Qu XG.(2009).7-Amino actinomycin D bound to single-stranded hairpin DNA enhanced by loop sequence-dependent luminescent Eu3+ and Tb3+ binding.journal of inorganic biochemistry,103(12),1675-1679. |
| MLA | Peng YH,et al."7-Amino actinomycin D bound to single-stranded hairpin DNA enhanced by loop sequence-dependent luminescent Eu3+ and Tb3+ binding".journal of inorganic biochemistry 103.12(2009):1675-1679. |
入库方式： OAI收割
来源：长春应用化学研究所
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