Spectral and electrochemical detection of protonated triplex formation by a small-molecule anticancer agent
文献类型：期刊论文
| 作者 | Feng LY ; Li X ; Peng YH ; Geng J ; Ren JS ; Qu XG |
| 刊名 | chemical physics letters
 |
| 出版日期 | 2009 |
| 卷号 | 480期号:4-6页码:309-312 |
| 关键词 | DNA FLANKING SEQUENCE BINDING LIGANDS STRUCTURAL SELECTIVITY THERMODYNAMIC ANALYSIS GOLD ELECTRODES BASE-STACKING CYTOCHROME-C ACID COMPLEX B-FORM STABILIZATION |
| ISSN号 | 0009-2614 |
| 通讯作者 | qu xg |
| 中文摘要 | triplex helical formation has been the focus of considerable interest because of possible applications in developing new molecular biology tools as well as therapeutic agents and the possible relevance of h-dna structures in biology system. we report here that a small-molecule anticancer agent, coralyne, has binding preference to the less stable protonated triplex d(c+-t)(6):d(a-g)(6).d(c-t)(6) over duplex d(a-g)(6).d(c-t)(6) and shows different spectral and electrochemical characteristics when binding to triplex and duplex dna, indicating that electrochemical technique can detect the less stable protonated triplex formation. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000270423000031 |
| 公开日期 | 2010-06-18 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/12719]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Feng LY,Li X,Peng YH,et al. Spectral and electrochemical detection of protonated triplex formation by a small-molecule anticancer agent[J]. chemical physics letters,2009,480(4-6):309-312. |
| APA | Feng LY,Li X,Peng YH,Geng J,Ren JS,&Qu XG.(2009).Spectral and electrochemical detection of protonated triplex formation by a small-molecule anticancer agent.chemical physics letters,480(4-6),309-312. |
| MLA | Feng LY,et al."Spectral and electrochemical detection of protonated triplex formation by a small-molecule anticancer agent".chemical physics letters 480.4-6(2009):309-312. |
入库方式： OAI收割
来源：长春应用化学研究所
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