Small-Molecule Selectively Recognizes Human Telomeric G-Quadruplex DNA and Regulates Its Conformational Switch
文献类型：期刊论文
| 作者 | Chen ML ; Song GT ; Wang CY ; Hu D ; Ren JS ; Qu XG |
| 刊名 | biophysical journal
 |
| 出版日期 | 2009 |
| 卷号 | 97期号:7页码:2014-2023 |
| 关键词 | G-QUARTET DNA STABILIZING LIGANDS DRUG DESIGN K+ SOLUTION G-TETRAPLEX IN-VIVO BINDING REPEAT TELOMESTATIN INHIBITION |
| ISSN号 | 0006-3495 |
| 通讯作者 | ren js |
| 中文摘要 | structural complexity is an inherent feature of the human telomeric sequence, and it presents a major challenge for developing ligands of pharmaceutical interest. recent studies have pointed out that the induction of a quadruplex or change of a quadruplex conformation on binding may be the most powerful method to exert the desired biological effect. in this study, we demonstrate a quadruplex ligand that binds selectively to different forms of the human telomeric g-quadruplex structure and regulates its conformational switch. the results show that not only can oxazine750 selectively induce parallel quadruplex formation from a random coil telomeric oligonucleotide, in the absence of added cations, it also can easily surpass the energy barrier between two structures and change the g-quadruplex conformation in na+ or k+ solution. the combination of its unique properties, including the size and shape of the g-quadruplex and the small molecule, is proposed as the predominant force for regulating the special structural formation and transitions. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000270586000024 |
| 公开日期 | 2010-06-18 |
| 源URL | [http://202.98.16.49/handle/322003/12727]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Chen ML,Song GT,Wang CY,et al. Small-Molecule Selectively Recognizes Human Telomeric G-Quadruplex DNA and Regulates Its Conformational Switch[J]. biophysical journal,2009,97(7):2014-2023. |
| APA | Chen ML,Song GT,Wang CY,Hu D,Ren JS,&Qu XG.(2009).Small-Molecule Selectively Recognizes Human Telomeric G-Quadruplex DNA and Regulates Its Conformational Switch.biophysical journal,97(7),2014-2023. |
| MLA | Chen ML,et al."Small-Molecule Selectively Recognizes Human Telomeric G-Quadruplex DNA and Regulates Its Conformational Switch".biophysical journal 97.7(2009):2014-2023. |
入库方式： OAI收割
来源：长春应用化学研究所
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