Evaluation of Effects of Bivalent Cations on the Formation of Purine-rich Triple-Helix DNA by ESI-FT-MS
文献类型：期刊论文
| 作者 | Wan CH ; Cui M ; Song FR ; Liu ZQ ; Liu SY |
| 刊名 | journal of the american society for mass spectrometry
 |
| 出版日期 | 2009 |
| 卷号 | 20期号:7页码:1281-1286 |
| 关键词 | IONIZATION MASS-SPECTROMETRY DIVALENT METAL-CATIONS G-QUADRUPLEX BINDING APTAMER REPEAT STABILIZATION STABILITY RESONANCE GENE |
| ISSN号 | 1044-0305 |
| 通讯作者 | liu sy |
| 中文摘要 | the gga triplet repeats are widely dispersed throughout eukaryotic genomes. (gga)n or (ggt)n oligonucleotides can interact with double-stranded dna containing (gga:cct)n to form triple-stranded dna. the effects of 8 divalent metal ions (3 alkaline-earth metals and 5 transition metals) on formation of these purine-rich triple-helix dna were investigated by electrospray ionization fourier transform ion cyclotron resonance mass spectrometry (esi-ft-ms). in the absence of metal ions, no triplex but single-strand, duplex, and purine homodimer ions were observed in mass spectra. the triple-helix dna complexes were observed only in the presence of certain divalent ions. the effects of different divalent cations on the formation of purine-rich triplexes were compared. transition-metal ions, especially co2+ and ni2+, significantly boost the formation of triple-helix dna, whereas alkaline-earth metal ions have no positive effects on triplex formation. in addition, ba2+ is notably beneficial to the formation of homodimer instead of triplex. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000268035800007 |
| 公开日期 | 2010-06-18 |
| 源URL | [http://202.98.16.49/handle/322003/12819]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wan CH,Cui M,Song FR,et al. Evaluation of Effects of Bivalent Cations on the Formation of Purine-rich Triple-Helix DNA by ESI-FT-MS[J]. journal of the american society for mass spectrometry,2009,20(7):1281-1286. |
| APA | Wan CH,Cui M,Song FR,Liu ZQ,&Liu SY.(2009).Evaluation of Effects of Bivalent Cations on the Formation of Purine-rich Triple-Helix DNA by ESI-FT-MS.journal of the american society for mass spectrometry,20(7),1281-1286. |
| MLA | Wan CH,et al."Evaluation of Effects of Bivalent Cations on the Formation of Purine-rich Triple-Helix DNA by ESI-FT-MS".journal of the american society for mass spectrometry 20.7(2009):1281-1286. |
入库方式： OAI收割
来源：长春应用化学研究所
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