Kinetics and Statistical Distributions of Single-Molecule Conformational Dynamics
文献类型：期刊论文
| 作者 | Lu Q ; Wang J |
| 刊名 | journal of physical chemistry b
 |
| 出版日期 | 2009 |
| 卷号 | 113期号:5页码:1517-1521 |
| 关键词 | ADENYLATE KINASE ENERGY LANDSCAPES ESCHERICHIA-COLI TRANSITION-STATE NETWORK MODEL CATALYSIS PROTEINS MOTIONS SIMULATION MECHANISM |
| ISSN号 | 1520-6106 |
| 通讯作者 | wang j |
| 中文摘要 | we developed a coarse-grained yet microscopic detailed model to study the statistical fluctuations of single-molecule protein conformational dynamics of adenylate kinase. we explored the underlying conformational energy landscape and found that the system has two basins of attractions, open and closed conformations connected by two separate pathways. the kinetics is found to be nonexponential, consistent with single-molecule conformational dynamics experiments. furthermore, we found that the statistical distribution of the kinetic times for the conformational transition has a long power law tail, reflecting the exponential density of state of the underlying landscape. we also studied the joint distribution of the two pathways and found memory effects. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000262902600036 |
| 公开日期 | 2010-06-18 |
| 源URL | [http://202.98.16.49/handle/322003/12899]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Lu Q,Wang J. Kinetics and Statistical Distributions of Single-Molecule Conformational Dynamics[J]. journal of physical chemistry b,2009,113(5):1517-1521. |
| APA | Lu Q,&Wang J.(2009).Kinetics and Statistical Distributions of Single-Molecule Conformational Dynamics.journal of physical chemistry b,113(5),1517-1521. |
| MLA | Lu Q,et al."Kinetics and Statistical Distributions of Single-Molecule Conformational Dynamics".journal of physical chemistry b 113.5(2009):1517-1521. |
入库方式： OAI收割
来源：长春应用化学研究所
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