Oxygen Carrier Based on Hemoglobin/Poly(L-lysine)-block-poly(L-phenylalanine) Vesicles
文献类型：期刊论文
| 作者 | Sun J ; Huang YB ; Shi Q ; Chen XS ; Jing XB |
| 刊名 | langmuir
 |
| 出版日期 | 2009 |
| 卷号 | 25期号:24页码:13726-13729 |
| 关键词 | BLOOD SUBSTITUTES NITRIC-OXIDE HEMOGLOBIN CELLS NANOBIOTECHNOLOGY COPOLYMERS |
| ISSN号 | 0743-7463 |
| 通讯作者 | jing xb |
| 中文摘要 | an oxygen carrier was prepared by encapsulating carbonylated hemoglobin (co-hb) molecules into polypeptide vesicles made from poly(l-lysine)-block-poly(l-phenylalanine) (pll-b-ppa) diblock copolymers in aqueous medium at ph 5.8. the encapsulation was confirmed by confocal laser scanning microscopy (clsm). the morphology and size of the vesicles were studied by field-emission scanning electron microscopy (esem). they had a spherical shape with it mean diameter of about 4 to 5 mu m. the encapsulation efficiency of hemoglobin was 40 wt %, and the hemoglobin content in the vesicles was 32 wt %. the co-hb encapsulated in the pll-b-ppa vesicles was more stable than free co-hb under ambient conditions, in the presence of a o-2 atmosphere, the co-hb in the vesicle could be converted into oxygen-binding hemoglobin (o-2-hb) under irradiation of visible light for 2 h. therefore, the co-hb/pll-b-ppa vesicles are expected to be used its red blood cell substitutes. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000272394400005 |
| 公开日期 | 2010-06-18 |
| 源URL | [http://202.98.16.49/handle/322003/12913]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Sun J,Huang YB,Shi Q,et al. Oxygen Carrier Based on Hemoglobin/Poly(L-lysine)-block-poly(L-phenylalanine) Vesicles[J]. langmuir,2009,25(24):13726-13729. |
| APA | Sun J,Huang YB,Shi Q,Chen XS,&Jing XB.(2009).Oxygen Carrier Based on Hemoglobin/Poly(L-lysine)-block-poly(L-phenylalanine) Vesicles.langmuir,25(24),13726-13729. |
| MLA | Sun J,et al."Oxygen Carrier Based on Hemoglobin/Poly(L-lysine)-block-poly(L-phenylalanine) Vesicles".langmuir 25.24(2009):13726-13729. |
入库方式： OAI收割
来源：长春应用化学研究所
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