Folate-Conjugated Micelles and Their Folate-Receptor-Mediated Endocytosis
文献类型：期刊论文
| 作者 | Lu TC ; Sun J ; Chen XX ; Zhang PB ; Jing XB |
| 刊名 | macromolecular bioscience
 |
| 出版日期 | 2009 |
| 卷号 | 9期号:11页码:1059-1068 |
| 关键词 | BLOCK-COPOLYMER MICELLES ANTICANCER DRUG-DELIVERY BRAIN ENDOTHELIAL-CELLS POLYMERIC MICELLES TUMOR-CELLS CANCER-CELLS IN-VITRO DOXORUBICIN NANOPARTICLES PH |
| ISSN号 | 1616-5187 |
| 通讯作者 | jing xb |
| 中文摘要 | a folate-conjugated copolymer peg-pla-pll/folate was synthesized and mixed with pure peg-pla-pll and a fluorescent model drug mfitc to prepare folate-conjugated micelles. the distribution of micelles was studied on cancer-cell-bearing mice via frozen slicing. the results show that mfitc is successfully encapsulated into folate(+) and folate(-)micelles; peg-pla-pll micelles the latter can be internalized by both hela and cho cells without selectivity due to their cationic surface charges, while folate(+)micelles exhibit more preferential endocytosis by hela cells than by cho cells. the folate(-)micelles showed retention in both organs and tumors. the folate(+)micelles are a promising active targeting drug delivery system for fr over-expressing cells and they accumulate in tumor beds. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000271990000002 |
| 公开日期 | 2010-06-18 |
| 源URL | [http://202.98.16.49/handle/322003/12917]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Lu TC,Sun J,Chen XX,et al. Folate-Conjugated Micelles and Their Folate-Receptor-Mediated Endocytosis[J]. macromolecular bioscience,2009,9(11):1059-1068. |
| APA | Lu TC,Sun J,Chen XX,Zhang PB,&Jing XB.(2009).Folate-Conjugated Micelles and Their Folate-Receptor-Mediated Endocytosis.macromolecular bioscience,9(11),1059-1068. |
| MLA | Lu TC,et al."Folate-Conjugated Micelles and Their Folate-Receptor-Mediated Endocytosis".macromolecular bioscience 9.11(2009):1059-1068. |
入库方式： OAI收割
来源：长春应用化学研究所
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