Feasibility of biodegradable PLGA common bile duct stents: An in vitro and in vivo study
文献类型：期刊论文
| 作者 | Xu XY ; Liu TJ ; Liu SH ; Zhang K ; Shen Z ; Li YX ; Jing XB |
| 刊名 | journal of materials science-materials in medicine
 |
| 出版日期 | 2009 |
| 卷号 | 20期号:5页码:1167-1173 |
| ISSN号 | 0957-4530 |
| 关键词 | LAPAROSCOPIC CHOLEDOCHOTOMY METALLIC STENT BILIARY STENT CHOLEDOCHOLITHIASIS CHOLANGIOCARCINOMA CHOLECYSTECTOMY EXPLORATION STRATEGIES CLOSURE BONE |
| 通讯作者 | jing xb |
| 中文摘要 | the current study investigates the feasibility of using a biodegradable polymeric stent in common bile duct (cbd) repair and reconstruction. here, poly(l-lactide-co-glycolide) (plga, molar ratio la/ga = 80/20) was processed into a circular tube- and dumbbell-shaped specimens to determine the in vitro degradation behavior in bile. the morphology, weight loss, and molecular weight changes were then investigated in conjunction with evaluations of the mechanical properties of the specimen. circular tube-shaped plga stents with x-ray opacity were subsequently used in common bile duct exploration (cbde) and primary suturing in canine models. next, x-ray images of cbd stents in vivo were compared and levels of serum liver enzymes and a histological analysis were conducted after stent transplantation. the results showed that the plga stents exhibited the required biomedical properties and spontaneously disappeared from cbds in 4-5 weeks. the degradation period and function match the requirements in repair and reconstruction of cbds to support the duct, guide bile drainage, and reduce t-tube-related complications. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000264837700017 |
| 公开日期 | 2010-06-18 |
| 源URL | [http://202.98.16.49/handle/322003/12919]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xu XY,Liu TJ,Liu SH,et al. Feasibility of biodegradable PLGA common bile duct stents: An in vitro and in vivo study[J]. journal of materials science-materials in medicine,2009,20(5):1167-1173. |
| APA | Xu XY.,Liu TJ.,Liu SH.,Zhang K.,Shen Z.,...&Jing XB.(2009).Feasibility of biodegradable PLGA common bile duct stents: An in vitro and in vivo study.journal of materials science-materials in medicine,20(5),1167-1173. |
| MLA | Xu XY,et al."Feasibility of biodegradable PLGA common bile duct stents: An in vitro and in vivo study".journal of materials science-materials in medicine 20.5(2009):1167-1173. |
入库方式： OAI收割
来源：长春应用化学研究所
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