A study of the non-covalent interaction between flavonoids and DNA triplexes by electrospray ionization mass spectrometry
文献类型：期刊论文
| 作者 | Wan CH ; Cui M ; Song FR ; Liu ZQ ; Liu SY |
| 刊名 | international journal of mass spectrometry
 |
| 出版日期 | 2009 |
| 卷号 | 283期号:1-3页码:48-55 |
| 关键词 | TOPOISOMERASE-I G-QUADRUPLEX NATURAL-PRODUCTS AMINO SUGAR DUPLEX DNA ESI-MS BINDING COMPLEXES QUERCETIN AFFINITY |
| ISSN号 | 1387-3806 |
| 通讯作者 | liu sy |
| 中文摘要 | the binding interactions of 22 flavonoids (9 aglycones and 13 glycosides) with dna triplexes were investigated using electrospray ionization mass spectrometry (esi-ms). the results revealed that the hydroxyl positions of aglycones. the locations and numbers of saccharide, as well as the aglycone skeletons play roles in the triplex-binding properties of flavonoids. the presence of 3-oh, or 3'-oh, or replacement of 4'-oh with methoxy group in aglycones decreased the fraction of bound dna sharply. flavonoid glycosides exhibit higher binding affinities towards the dna triplexes than their aglycone counterparts. glycosylations of flavones at the 8-c position and isoflavones at the 7-o position show higher binding affinities than those on the other positions of ring a of aglycones. glycosylation with a disaccharide on 0 position of flavonol results in higher binding affinity than that with monosaccharide. flexibility of the ring b is favorable for its interaction with dna triplex. according to sustained off-resonance irradiation collision-induced dissociation (sori-cid) experiments, glycosylation and non-planarity of flavonoid aglycones lead to different dissociation pathways of the flavonoid/triplex complexes. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000266808800009 |
| 公开日期 | 2010-06-18 |
| 源URL | [http://202.98.16.49/handle/322003/12927]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wan CH,Cui M,Song FR,et al. A study of the non-covalent interaction between flavonoids and DNA triplexes by electrospray ionization mass spectrometry[J]. international journal of mass spectrometry,2009,283(1-3):48-55. |
| APA | Wan CH,Cui M,Song FR,Liu ZQ,&Liu SY.(2009).A study of the non-covalent interaction between flavonoids and DNA triplexes by electrospray ionization mass spectrometry.international journal of mass spectrometry,283(1-3),48-55. |
| MLA | Wan CH,et al."A study of the non-covalent interaction between flavonoids and DNA triplexes by electrospray ionization mass spectrometry".international journal of mass spectrometry 283.1-3(2009):48-55. |
入库方式： OAI收割
来源：长春应用化学研究所
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