Preparation and Bioactivity of the Composite of PLGA and Hydroxyapatite Nanocrystals Surface-grafted with L-lactic Acid Oligomer
文献类型：期刊论文
| 作者 | Yu T ; Liu Y ; Wang Y ; Jing XB ; Zhang PB ; Chen XS |
| 刊名 | chemical journal of chinese universities-chinese
 |
| 出版日期 | 2009 |
| 卷号 | 30期号:7页码:1439-1444 |
| ISSN号 | 0251-0790 |
| 通讯作者 | liu y |
| 中文摘要 | the hydroxyapatite (ha) nanocrystals of 100-200 nm in length and 20-30 nm in width were hydrothermally synthesized by the reaction of phosphoric acid and calcium hydroxide. lactic acid oligomer surface grafted ha(op-ha) nanoparticles were obtained by oligomeric lactic acid with a certain molecular weight grafting onto the ha surface to form a ca carboxylate bond in the absence of any catalyst. the op-ha was further blended with poly(lactide-co-glycolide) (plga) to prepare the nanocomposite of op-ha/plga. ftir, tga, esem and edx were used to analyze grafting reaction, the graft ratio of op-ha, surface topography and calcium deposition of the composites, respectively. the rabbit osteoblasts were seeded and cultured on the surface of composites in vitro. the cell morphology, adhesion, proliferation and gene expression were evaluated with fitc staining, nih image j software and the analysis of real-time pcr, respectively. the results show that the graft ratio of op-ha is 8.3% (mass fraction). the op-ha/plga nanocomposite possessed more suitable surface properties, including roughness and plenty of calcium and phosphor. it exhibited better cell adhesion, spreading and proliferation of rabbit osteoblasts, compared to pure plga. |
| 收录类别 | SCI |
| 语种 | 中文 |
| WOS记录号 | WOS:000268467100038 |
| 公开日期 | 2010-06-18 |
| 源URL | [http://202.98.16.49/handle/322003/12931]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Yu T,Liu Y,Wang Y,et al. Preparation and Bioactivity of the Composite of PLGA and Hydroxyapatite Nanocrystals Surface-grafted with L-lactic Acid Oligomer[J]. chemical journal of chinese universities-chinese,2009,30(7):1439-1444. |
| APA | Yu T,Liu Y,Wang Y,Jing XB,Zhang PB,&Chen XS.(2009).Preparation and Bioactivity of the Composite of PLGA and Hydroxyapatite Nanocrystals Surface-grafted with L-lactic Acid Oligomer.chemical journal of chinese universities-chinese,30(7),1439-1444. |
| MLA | Yu T,et al."Preparation and Bioactivity of the Composite of PLGA and Hydroxyapatite Nanocrystals Surface-grafted with L-lactic Acid Oligomer".chemical journal of chinese universities-chinese 30.7(2009):1439-1444. |
入库方式： OAI收割
来源：长春应用化学研究所
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