Synthesis, self-assembly in water, and cytotoxicity of MPEG-block-PLLA/DX conjugates
文献类型：期刊论文
| 作者 | Me ZG ; Lu TC ; Chen XS ; Zheng YH ; Jing XB |
| 刊名 | journal of biomedical materials research part a
 |
| 出版日期 | 2009 |
| 卷号 | 88a期号:1页码:238-245 |
| 关键词 | IN-VITRO PACLITAXEL NANOPARTICLES COPOLYMERS MICELLE DOCETAXEL DELIVERY ANALOGS TAXOL CORE |
| ISSN号 | 1549-3296 |
| 通讯作者 | jing xb |
| 中文摘要 | docetaxel (dx) is one of the most effective antineoplastic drugs. its current clinical administration is limited because of its hydrophobicity and serious side effects. a polymer/dx conjugate is designed and successfully prepared to solve these problems. it is monomethoxy-poly(ethylene glycol)-block-poly(l-lactide)/dx (mpeg-plla/dx) it was synthesized by reacting dx with carboxyl-terminated copolymer mpeg-plla, which was prepared by reacting succinic anhydride with hydroxyl-terminated copolymer monomethoxy-poly(ethylene glycol)-block-poly (l-lactide) (mpeg-plla). its structure and molecular weight was confirmed by h-1 nmr and gpc. the mpeg-plla/dx micelles in aqueous solution were prepared using a so]vent displacement method and characterized by dynamic light scattering for size and size distribution, and by transmission electron microscopy for surface morphology. its antitumor activity against hela cancer cells evaluated by mtt assay showed that it had a similar antitumor activity to pure d at the same drug content. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000261471900023 |
| 公开日期 | 2010-06-18 |
| 源URL | [http://202.98.16.49/handle/322003/12943]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Me ZG,Lu TC,Chen XS,et al. Synthesis, self-assembly in water, and cytotoxicity of MPEG-block-PLLA/DX conjugates[J]. journal of biomedical materials research part a,2009,88a(1):238-245. |
| APA | Me ZG,Lu TC,Chen XS,Zheng YH,&Jing XB.(2009).Synthesis, self-assembly in water, and cytotoxicity of MPEG-block-PLLA/DX conjugates.journal of biomedical materials research part a,88a(1),238-245. |
| MLA | Me ZG,et al."Synthesis, self-assembly in water, and cytotoxicity of MPEG-block-PLLA/DX conjugates".journal of biomedical materials research part a 88a.1(2009):238-245. |
入库方式： OAI收割
来源：长春应用化学研究所
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