Glycyrrhetinic acid-modified nanoparticles for drug delivery: Preparation and characterization
文献类型：期刊论文
| 作者 | Tian Q ; Wang W ; He XT ; Zhu XC ; Huang W ; Zhang CN ; Yuan Z ; Chen XS |
| 刊名 | chinese science bulletin
 |
| 出版日期 | 2009 |
| 卷号 | 54期号:18页码:3121-3126 |
| ISSN号 | 1001-6538 |
| 关键词 | CHITOSAN NANOPARTICLES PROTEIN HEPATOCYTES BINDING |
| 通讯作者 | yuan z |
| 中文摘要 | in this work, glycyrrhetinic acid-modified chitosan (mga-suc-cts) used as liver targeted carrier for drug delivery, was prepared via hemisuccinate as a bridged group. the structure of the product was confirmed by ir and nmr methods and the degree of substitution (ds) of glycyrrhetinic acid groups was estimated via elemental analysis. nanoparticles were formed by ionic gelation methold. the drug-loading and release behavior of the nanoparticles were investigated using bsa as the model drug. the results indicated that the carrier with a highest ds of 5.19% could be got and the ds was controlled by changing reaction temperature or feed ratio. bsa could be entrapped into the nanoparticles with the drug-loading ratio of 26.3% and the encapsulation efficiency of 81.5%. a sustained release over an 11-day period was observed in ph 7.4 in vitro. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000269896500001 |
| 公开日期 | 2010-06-18 |
| 源URL | [http://202.98.16.49/handle/322003/12945]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Tian Q,Wang W,He XT,et al. Glycyrrhetinic acid-modified nanoparticles for drug delivery: Preparation and characterization[J]. chinese science bulletin,2009,54(18):3121-3126. |
| APA | Tian Q.,Wang W.,He XT.,Zhu XC.,Huang W.,...&Chen XS.(2009).Glycyrrhetinic acid-modified nanoparticles for drug delivery: Preparation and characterization.chinese science bulletin,54(18),3121-3126. |
| MLA | Tian Q,et al."Glycyrrhetinic acid-modified nanoparticles for drug delivery: Preparation and characterization".chinese science bulletin 54.18(2009):3121-3126. |
入库方式： OAI收割
来源：长春应用化学研究所
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