Biodegradable amphiphilic polymer-drug conjugate micelles
文献类型：期刊论文
| 作者 | Hu XL ; Jing XB |
| 刊名 | expert opinion on drug delivery
 |
| 出版日期 | 2009 |
| 卷号 | 6期号:10页码:1079-1090 |
| 关键词 | BLOCK-COPOLYMER MICELLES RING-OPENING POLYMERIZATION IN-VITRO TRIBLOCK COPOLYMER ANTITUMOR AGENT EPSILON-CAPROLACTONES DIBLOCK COPOLYMERS CIRCULATION TIMES ANTICANCER DRUGS DELIVERY SYSTEMS |
| ISSN号 | 1742-5247 |
| 通讯作者 | jing xb |
| 中文摘要 | the coupling of drugs to macromolecular carriers received an important impetus from ringsdorf's notion of polymer-drug conjugates. several water-soluble polymers, poly(ethylene glycol), poly[n-(2-hydroxypropyl) methacrylamidel, poly(l-glutamic acid) and dextran, are studied intensively and have been utilized successfully in clinical research. the promising results arising from clinical trials with polymer-drug conjugates (e.g., paclitaxel, doxorubicin, camptothecins) have provided a firm foundation for other synthetic polymers, especially biodegradable polymers, used as drug delivery vehicles. this review discusses biodegradable polymeric micelles as an alternative drug-conjugate system. particular focus is on a-b or b-a-b type biodegradable amphiphilic block copolymer such as polylactide, morpholine-2,5-dione derivatives and cyclic carbonates, which can form a core-shell micellar structure, with the hydrophobic drug-binding segment forming the hydrophobic core and the hydrophilic segment as a hydrated outer shell. polymeric micelles can be designed to avoid uptake by cells of reticuloendothelial system and thus enhance their blood lifetime via the enhanced permeability and retention effect. |
| 收录类别 | 其它国际期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000271491200006 |
| 公开日期 | 2010-06-18 |
| 源URL | [http://202.98.16.49/handle/322003/12971]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Hu XL,Jing XB. Biodegradable amphiphilic polymer-drug conjugate micelles[J]. expert opinion on drug delivery,2009,6(10):1079-1090. |
| APA | Hu XL,&Jing XB.(2009).Biodegradable amphiphilic polymer-drug conjugate micelles.expert opinion on drug delivery,6(10),1079-1090. |
| MLA | Hu XL,et al."Biodegradable amphiphilic polymer-drug conjugate micelles".expert opinion on drug delivery 6.10(2009):1079-1090. |
入库方式： OAI收割
来源：长春应用化学研究所
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