Asymmetric Michael addition of aldehydes to nitroolefins catalyzed by L-prolinamide derivatives using phenols as co-catalysts
文献类型：期刊论文
| 作者 | Cheng YQ ; Bian Z ; He YB ; Han FS ; Kang CQ ; Ning ZL ; Gao LX |
| 刊名 | tetrahedron-asymmetry
 |
| 出版日期 | 2009 |
| 卷号 | 20期号:15页码:1753–1758 |
| 关键词 | ENANTIOSELECTIVE MICHAEL CONJUGATE ADDITION BETA-NITROSTYRENES PYRROLIDINE SULFONAMIDE ABSOLUTE-CONFIGURATION MOSHERS METHOD EFFICIENT NITROALKENES KETONES ORGANOCATALYSTS |
| ISSN号 | 0957-4166 |
| 通讯作者 | gao lx |
| 中文摘要 | the asymmetric michael addition of aldehydes to nitroolefins was investigated using l-prolinamide derivatives of 2-(2'-piperidinyl)pyridine as catalyst and a variety of phenols as co-catalyst. extensive screening toward the effect of prolinamides, phenols, and solvents on this transformation revealed that a combination of (s)-2-(2'-piperidinyl)pyridine-derived trans-4-hydroxy-l-prolinamide 2c, (s)-1,1'-bi-2-naphthol, and dichloromethane was a promising system. this system was shown to be amenable to a rich variety of aldehydes and nitroolefins and afforded the nitroaldehyde products with excellent yield, enantiomeric excess (up to 99%) and diastereoselectivity ratio (up to 99/1), even in the case of 1 mol % catalyst loading and 1.5 equiv of aldehydes. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000270126100010 |
| 公开日期 | 2010-06-18 |
| 源URL | [http://202.98.16.49/handle/322003/13021]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Cheng YQ,Bian Z,He YB,et al. Asymmetric Michael addition of aldehydes to nitroolefins catalyzed by L-prolinamide derivatives using phenols as co-catalysts[J]. tetrahedron-asymmetry,2009,20(15):1753–1758. |
| APA | Cheng YQ.,Bian Z.,He YB.,Han FS.,Kang CQ.,...&Gao LX.(2009).Asymmetric Michael addition of aldehydes to nitroolefins catalyzed by L-prolinamide derivatives using phenols as co-catalysts.tetrahedron-asymmetry,20(15),1753–1758. |
| MLA | Cheng YQ,et al."Asymmetric Michael addition of aldehydes to nitroolefins catalyzed by L-prolinamide derivatives using phenols as co-catalysts".tetrahedron-asymmetry 20.15(2009):1753–1758. |
入库方式： OAI收割
来源：长春应用化学研究所
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