Bimolecular quadruplexes and their transitions to higher-order molecular structures detected by ESI-FTICR-MS
文献类型：期刊论文
| 作者 | Guo XH ; Liu SY ; Yu Z |
| 刊名 | journal of the american society for mass spectrometry
 |
| 出版日期 | 2007 |
| 卷号 | 18期号:8页码:1467-1476 |
| 关键词 | IONIZATION MASS-SPECTROMETRY TELOMERIC DNA CIRCULAR-DICHROISM DIMERIC QUADRUPLEX OLIGONUCLEOTIDE K+ POTASSIUM SODIUM NA+ D(G(4)T(4)G(4)) |
| ISSN号 | 1044-0305 |
| 通讯作者 | liu sy |
| 中文摘要 | four individual quadruplexes, which are self-assembled in ammonium acetate solution from telomeric sequences of closely related dna strands - d(g(4)t(4)g(4)), d(g(3)t(4)g(4)), d(g(3)t(4)g(3)), and d(g(4)t(4)g(3)) - have been detected in the gas phase using electrospray ionization fourier transform ion cyclotron resonance mass spectrometry (esi-fticr-ms). the bimolecular quadruplexes associate with the same number of nh4+ in the gas phase as nmr shows that they do in solution. the quadruplex structures formed in solution are maintained in the gas phase. furthermore, the mass spectra show that the bimolecular quadruplexes generated by the strands d(g(3)t(4)g(3)) and d(g(4)t(4)g(3)) are unstable, being converted into trimolecular and tetramolecular structures with increasing concentrations of nh4+ in the solution. circular dichroism (cd) spectra reveal structural changes during the process of strand stoichiometric transitions, in which the relative orientation of strands in the quadruplexes changes from an antiparallel to a parallel arrangement. such changes were observed for the strand d(g(4)t(4)g(3)), but not for the strand d(g(3)t(4)g(3)). the present work provides a significant insight into the formation of various dna quadruplexes, especially the higher-order species. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000248603700013 |
| 公开日期 | 2010-07-13 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/13313]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Guo XH,Liu SY,Yu Z. Bimolecular quadruplexes and their transitions to higher-order molecular structures detected by ESI-FTICR-MS[J]. journal of the american society for mass spectrometry,2007,18(8):1467-1476. |
| APA | Guo XH,Liu SY,&Yu Z.(2007).Bimolecular quadruplexes and their transitions to higher-order molecular structures detected by ESI-FTICR-MS.journal of the american society for mass spectrometry,18(8),1467-1476. |
| MLA | Guo XH,et al."Bimolecular quadruplexes and their transitions to higher-order molecular structures detected by ESI-FTICR-MS".journal of the american society for mass spectrometry 18.8(2007):1467-1476. |
入库方式： OAI收割
来源：长春应用化学研究所
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