Construction of a stable w/o nano-emulsion as a potential adjuvant for foot and mouth disease virus vaccine
文献类型：期刊论文
| 作者 | Chen, Zenghui1,2; Zhang, Songping1; Li, Zhengjun1,2; Ma, Guanghui1; Su, Zhiguo1 |
| 刊名 | ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
 |
| 出版日期 | 2017 |
| 卷号 | 45期号:5页码:897-906 |
| 关键词 | Adjuvant Foot-and-mouth Disease Vaccine Polyglycerol Polyricinoleate Stability W/o Nano-emulsion |
| ISSN号 | 2169-1401 |
| DOI | 10.1080/21691401.2016.1188396 |
| 文献子类 | Article |
| 英文摘要 | A stable and bio-compatible w/o nano-emulsion was developed as adjuvant for foot and mouth disease (FMD) vaccine with isopropyl myristate as oil phase, polyglycerol polyricinoleate, and Tween 80 as surfactants. Dissolving Tween 80 in aqueous phase decreased the droplet size and improved stability of the emulsion through narrowing size distribution, increasing viscosity, and reducing the interfacial tension between oil and water. The nano-emulsion was then formulated with inactivated FMD virus and ovalbumin to investigate its potential application as an adjuvant. Compared with commercial ISA-206 adjuvant, the novel w/o nano-emulsion was able to induce both humoral- and cell-mediated immune response. |
| WOS关键词 | Mineral-oil Adjuvants ; Polyglycerol Polyricinoleate ; Isopropyl Myristate ; Immune-responses ; Stability ; Caseinate ; Particle ; Sodium ; Mice ; Pigs |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000402039400006 |
| 资助机构 | National Natural Science Foundation of China(21336010) ; National High Technology Research and Development Program of China (863 Program)(2014AA021005 ; National Science and Technology Major Project(2013ZX10004606) ; 2014AA021006) |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/22623]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Zenghui,Zhang, Songping,Li, Zhengjun,et al. Construction of a stable w/o nano-emulsion as a potential adjuvant for foot and mouth disease virus vaccine[J]. ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY,2017,45(5):897-906. |
| APA | Chen, Zenghui,Zhang, Songping,Li, Zhengjun,Ma, Guanghui,&Su, Zhiguo.(2017).Construction of a stable w/o nano-emulsion as a potential adjuvant for foot and mouth disease virus vaccine.ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY,45(5),897-906. |
| MLA | Chen, Zenghui,et al."Construction of a stable w/o nano-emulsion as a potential adjuvant for foot and mouth disease virus vaccine".ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY 45.5(2017):897-906. |
入库方式： OAI收割
来源：过程工程研究所
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