Harnessing Phosphato-Platinum Bonding Induced Supramolecular Assembly for Systemic Cisplatin Delivery
文献类型：期刊论文
| 作者 | Hou, Yingqin1; Wang, Yaoyi1; Wang, Ruijue3; Bao, Weier2; Xi, Xiaobo2; Sun, Yunlong1; Yang, Shengtao3; Wei, Wei2; Lu, Hua1 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2017-05-31 |
| 卷号 | 9期号:21页码:17757-17768 |
| 关键词 | poly(phosphotyrosine) cisplatin ATP-responsive drug delivery iRGD |
| ISSN号 | 1944-8244 |
| 英文摘要 | To improve the therapeutic index of cisplatin (CDDP), we present here a new paradigm of drug-induced self-assembly by harnessing phosphato-platinum cornplexation. Specifically, we show that a phosphato-platinum cross-linked micelle (PpY/Pt) can be generated by using a block copolymer methoxy-poly(ethylene glycol)block-poly(L-phosphotyrosine) (mPEG-b-PpY). Coating of PpY/Pt with aR9-iRGD peptide by simple mixing affords a targeting micelle with near neutral-charged surface (iPpY/Pt). The micelles feature in well-controlled sizes below 50 nm and high, stability under physiological conditions, and can withstand various environmental stresses. Importantly, the micelles demonstrate on-demand drug release profiles in response to pathological cues such as high ATP concentration and acidic pH. In vitro, the micelles are efficiently internalized and almost equally potent compared to CDDP. Moreover, iPpY/Pt induce greater cytotoxicity than PpY/Pt in a 3D tumor spheroid model likely due to its deeper tumor penetration. In vivo, the micelles exhibit prolonged circulation half-lives, enhanced tumor accumulation, excellent tumor growth inhibition in a xenograft HeLa model and an orthotropic mammary 4T1 model, and improved safety profiles evidenced by the reduced nephrotoxicity. Together) this work demonstrates for the first time that phosphato-platinurn complexation can be exploited for effective delivery of CDDP, and suggests a paradigm shift of constructing nanosystems for other anticancer metallodrugs. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 研究领域[WOS] | Science & Technology - Other Topics ; Materials Science |
| 关键词[WOS] | ANTICANCER DRUG-DELIVERY ; ENHANCE THERAPEUTIC-EFFICACY ; RING-OPENING POLYMERIZATION ; OVARIAN-CANCER CELLS ; PT(IV) PRO-DRUG ; TARGETED DELIVERY ; CO-DELIVERY ; ANTITUMOR EFFICACY ; BLADDER-CANCER ; BREAST-CANCER |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000402691600011 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/22637]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | 1.Peking Univ, Beijing Natl Lab Mol Sci, Minist Educ,Coll Chem & Mol Engn, Ctr Soft Matter Sci & Engn,Key Lab Polymer Chem &, Beijing 100871, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 10090, Peoples R China 3.Southwest Univ Nationalities, Coll Chem & Environm Protect Engn, Chengdu 610041, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hou, Yingqin,Wang, Yaoyi,Wang, Ruijue,et al. Harnessing Phosphato-Platinum Bonding Induced Supramolecular Assembly for Systemic Cisplatin Delivery[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(21):17757-17768. |
| APA | Hou, Yingqin.,Wang, Yaoyi.,Wang, Ruijue.,Bao, Weier.,Xi, Xiaobo.,...&Lu, Hua.(2017).Harnessing Phosphato-Platinum Bonding Induced Supramolecular Assembly for Systemic Cisplatin Delivery.ACS APPLIED MATERIALS & INTERFACES,9(21),17757-17768. |
| MLA | Hou, Yingqin,et al."Harnessing Phosphato-Platinum Bonding Induced Supramolecular Assembly for Systemic Cisplatin Delivery".ACS APPLIED MATERIALS & INTERFACES 9.21(2017):17757-17768. |
入库方式： OAI收割
来源：过程工程研究所
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