Sol-gel transition characterization of thermosensitive hydrogels based on water mobility variation provided by low field NMR
文献类型：期刊论文
| 作者 | Li, Yaqiong1; Li, Xiunan2; Chen, Chao2; Zhao, Dawei2; Su, Zhiguo2,3; Ma, Guanghui2; Yu, Rong1 |
| 刊名 | JOURNAL OF POLYMER RESEARCH
 |
| 出版日期 | 2017-01-21 |
| 卷号 | 24期号:2 |
| 关键词 | LF-NMR T-2 Sol-gel transition Water mobility Microstructure |
| ISSN号 | 1022-9760 |
| 英文摘要 | Sol-gel transition properties play a key role in various applications of thermosensitive hydrogels, but conventional methods for studying the sol-gel transition have some limitations. For extensive characterization of the water-polymer interaction and microstructure change during sol-gel transition, we propose a rapid and nondestructive method based on monitoring water mobility through low field NMR (LF-NMR), and this was applied to chitosan/beta-glycerophosphate (CS/GP) hydrogels. The spin-spin relaxation time (T-2) that depicted water mobility was measured by LF-NMR within 90 s. The T-2 component corresponding to water protons trapped in polymer networks (T-21) was very sensitive to sol-gel transition. A remarkable decrease of T-21 value indicated obvious variations of water mobility when CS/GP was heated, and a turning point was observed on the T-21-time curve. The gel point associated with this turning point could be easily determined by fitting the T-21-time curves to a bilinear regression model, and the results showed good accuracy and repeatability owing to the nondestructive nature of LF-NMR. Variations in water components and microstructure of CS/GP caused by water migration after solidification were also analyzed by monitoring dynamic changes of T-2. This rapid, nondestructive method provides a powerful tool for studying the sol-gel transition of hydrogels. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Polymer Science |
| 研究领域[WOS] | Polymer Science |
| 关键词[WOS] | IN-SITU ; TRIBLOCK COPOLYMER ; CONTROLLED-RELEASE ; KAPPA-CARRAGEENAN ; BISCUIT DOUGH ; LUNG INJURY ; GELATION ; CHITOSAN ; TEMPERATURE ; RELAXATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000400379400001 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/22843]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | 1.Sichuan Univ, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst, Minist Educ, Chengdu 610041, Peoples R China 2.Chinese Acad Sci, Natl Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China 3.Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Nanjing 210023, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yaqiong,Li, Xiunan,Chen, Chao,et al. Sol-gel transition characterization of thermosensitive hydrogels based on water mobility variation provided by low field NMR[J]. JOURNAL OF POLYMER RESEARCH,2017,24(2). |
| APA | Li, Yaqiong.,Li, Xiunan.,Chen, Chao.,Zhao, Dawei.,Su, Zhiguo.,...&Yu, Rong.(2017).Sol-gel transition characterization of thermosensitive hydrogels based on water mobility variation provided by low field NMR.JOURNAL OF POLYMER RESEARCH,24(2). |
| MLA | Li, Yaqiong,et al."Sol-gel transition characterization of thermosensitive hydrogels based on water mobility variation provided by low field NMR".JOURNAL OF POLYMER RESEARCH 24.2(2017). |
入库方式： OAI收割
来源：过程工程研究所
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