Single molecule dynamics and statistical fluctuations of gene regulatory networks: A repressilator
文献类型：期刊论文
| 作者 | Kim KY ; Lepzelter D ; Wang J |
| 刊名 | journal of chemical physics
 |
| 出版日期 | 2007 |
| 卷号 | 126期号:3页码:文献编号：034702 |
| 关键词 | FIELD-THEORY EXPRESSION NOISE CELLS ULTRASENSITIVITY SWITCHES |
| ISSN号 | 0021-9606 |
| 通讯作者 | wang j |
| 中文摘要 | the authors developed a time dependent method to study the single molecule dynamics of a simple gene regulatory network: a repressilator with three genes mutually repressing each other. they quantitatively characterize the time evolution dynamics of the repressilator. furthermore, they study purely dynamical issues such as statistical fluctuations and noise evolution. they illustrated some important features of the biological network such as monostability, spirals, and limit cycle oscillation. explicit time dependent fano factors which describe noise evolution and show statistical fluctuations out of equilibrium can be significant and far from the poisson distribution. they explore the phase space and the interrelationships among fluctuations, order, amplitude, and period of oscillations of the repressilators. the authors found that repressilators follow ordered limit cycle orbits and are more likely to appear in the lower fluctuating regions. the amplitude of the repressilators increases as the suppressing of the genes decreases and production of proteins increases. the oscillation period of the repressilators decreases as the suppressing of the genes decreases and production of proteins increases. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000243586200033 |
| 公开日期 | 2010-07-13 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/14033]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Kim KY,Lepzelter D,Wang J. Single molecule dynamics and statistical fluctuations of gene regulatory networks: A repressilator[J]. journal of chemical physics,2007,126(3):文献编号：034702. |
| APA | Kim KY,Lepzelter D,&Wang J.(2007).Single molecule dynamics and statistical fluctuations of gene regulatory networks: A repressilator.journal of chemical physics,126(3),文献编号：034702. |
| MLA | Kim KY,et al."Single molecule dynamics and statistical fluctuations of gene regulatory networks: A repressilator".journal of chemical physics 126.3(2007):文献编号：034702. |
入库方式： OAI收割
来源：长春应用化学研究所
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