Dynamics and intrinsic statistical fluctuations of a gene switch
文献类型：期刊论文
| 作者 | Lepzelter D ; Kim KY ; Wang J |
| 刊名 | journal of physical chemistry b
 |
| 出版日期 | 2007 |
| 卷号 | 111期号:34页码:10239-10247 |
| 关键词 | ESCHERICHIA-COLI FIELD-THEORY EXPRESSION NETWORK NOISE CELLS ULTRASENSITIVITY STOCHASTICITY STABILITY MOLECULE |
| ISSN号 | 1520-6106 |
| 通讯作者 | wang j |
| 中文摘要 | we studied a simple gene regulatory network, the toggle switch. specifically, we examined the means and statistical fluctuations in numbers of proteins. we found that when omega, the ratio of rates of protein-gene unbinding to protein degradation, was between similar to 10(-3) and similar to 10, the fluctuations were much larger than those we would have expected from poisson statistics. in addition, we examined characteristic time values for system relaxation and found both that they increased with omega and that they have significant phase transition effects, with a secondary time scale appearing near the boundary between bistable and other phases. last, we discuss the bistability of the toggle switch. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000248929900026 |
| 公开日期 | 2010-07-13 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/14063]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Lepzelter D,Kim KY,Wang J. Dynamics and intrinsic statistical fluctuations of a gene switch[J]. journal of physical chemistry b,2007,111(34):10239-10247. |
| APA | Lepzelter D,Kim KY,&Wang J.(2007).Dynamics and intrinsic statistical fluctuations of a gene switch.journal of physical chemistry b,111(34),10239-10247. |
| MLA | Lepzelter D,et al."Dynamics and intrinsic statistical fluctuations of a gene switch".journal of physical chemistry b 111.34(2007):10239-10247. |
入库方式： OAI收割
来源：长春应用化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。