Quantifying robustness and dissipation cost of yeast cell cycle network: The funneled energy landscape perspectives
文献类型：期刊论文
| 作者 | Han B ; Wang J |
| 刊名 | biophysical journal
 |
| 出版日期 | 2007 |
| 卷号 | 92期号:11页码:3755-3763 |
| 关键词 | GENE-EXPRESSION DYNAMICS ULTRASENSITIVITY STABILITY SYSTEMS NOISE MODEL |
| ISSN号 | 0006-3495 |
| 通讯作者 | wang j |
| 中文摘要 | we study the origin of robustness of yeast cell cycle cellular network through uncovering its underlying energy landscape. this is realized from the information of the steady-state probabilities by solving a discrete set of kinetic master equations for the network. we discovered that the potential landscape of yeast cell cycle network is funneled toward the global minimum, g1 state. the ratio of the energy gap between g1 and average versus roughness of the landscape termed as robustness ratio ( rr) becomes a quantitative measure of the robustness and stability for the network. the funneled landscape is quite robust against random perturbations from the inherent wiring or connections of the network. there exists a global phase transition between the more sensitive response or less self-degradation phase leading to underlying funneled global landscape with large rr, and insensitive response or more self-degradation phase leading to shallower underlying landscape of the network with small rr. furthermore, we show that the more robust landscape also leads to less dissipation cost of the network. least dissipation and robust landscape might be a realization of darwinian principle of natural selection at cellular network level. it may provide an optimal criterion for network wiring connections and design. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000246401800002 |
| 公开日期 | 2010-07-13 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/14065]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Han B,Wang J. Quantifying robustness and dissipation cost of yeast cell cycle network: The funneled energy landscape perspectives[J]. biophysical journal,2007,92(11):3755-3763. |
| APA | Han B,&Wang J.(2007).Quantifying robustness and dissipation cost of yeast cell cycle network: The funneled energy landscape perspectives.biophysical journal,92(11),3755-3763. |
| MLA | Han B,et al."Quantifying robustness and dissipation cost of yeast cell cycle network: The funneled energy landscape perspectives".biophysical journal 92.11(2007):3755-3763. |
入库方式： OAI收割
来源：长春应用化学研究所
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