Time-dependent DNA condensation induced by amyloid beta-peptide
文献类型：期刊论文
| 作者 | Yu HJ ; Ren JS ; Qu XG |
| 刊名 | biophysical journal
 |
| 出版日期 | 2007 |
| 卷号 | 92期号:1页码:185-191 |
| 关键词 | RECOMBINANT PRION PROTEIN ALZHEIMERS-DISEASE HELICAL TRANSITIONS NEURONAL APOPTOSIS SUPERCOILED DNA ACID COMPLEX AGGREGATION CONFORMATION POLYMERIZATION NEUROTOXICITY |
| ISSN号 | 0006-3495 |
| 通讯作者 | qu xg |
| 中文摘要 | the major protein component of the amyloid deposition in alzheimer's disease is a 39-43 residue peptide, amyloid beta (a beta). a beta is toxic to neurons, although the mechanism of neurodegeneration is uncertain. evidence exists for non-b dna conformation in the hippocampus of alzheimer's disease brains, and a beta was reportedly able to transform dna conformation in vitro. in this study, we found that dna conformation was altered in the presence of a beta, and a beta induced dna condensation in a time-dependent manner. furthermore, a beta sheets, serving as condensation nuclei, were crucial for dna condensation, and cu2+ and zn2+ ions inhibited a beta sheet-induced dna condensation. our results suggest dna condensation as a mechanism of a beta toxicity. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000242754300023 |
| 公开日期 | 2010-07-13 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/14103]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Yu HJ,Ren JS,Qu XG. Time-dependent DNA condensation induced by amyloid beta-peptide[J]. biophysical journal,2007,92(1):185-191. |
| APA | Yu HJ,Ren JS,&Qu XG.(2007).Time-dependent DNA condensation induced by amyloid beta-peptide.biophysical journal,92(1),185-191. |
| MLA | Yu HJ,et al."Time-dependent DNA condensation induced by amyloid beta-peptide".biophysical journal 92.1(2007):185-191. |
入库方式： OAI收割
来源：长春应用化学研究所
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