Daunomycin binding to detergent micelles: A model system for evaluating the hydrophobic contribution to drug-DNA interactions
文献类型：期刊论文
| 作者 | Dignam JD ; Qu XG ; Ren JS ; Chaires JB |
| 刊名 | journal of physical chemistry b
 |
| 出版日期 | 2007 |
| 卷号 | 111期号:39页码:11576-11584 |
| 关键词 | BENZOTHIOPYRANOINDAZOLE ANTICANCER ANALOGS NEGATIVELY-CHARGED PHOSPHOLIPIDS MOLECULAR-DYNAMICS SIMULATION POLYELECTROLYTE LIMITING LAWS HELIX-COIL TRANSITION ANTHRACYCLINE ANTIBIOTICS INTERCALATION REACTIONS TITRATION CALORIMETRY ACIDIC PHOSPHOLIPIDS LIPID-COMPOSITION |
| ISSN号 | 1520-6106 |
| 通讯作者 | dignam jd |
| 中文摘要 | the interaction of daunomycin with sodium dodecyl sulfate and triton x-100 micelles was investigated as a model for the hydrophobic contribution to the free energy of dna intercalation reactions. measurements of visible absorbance, fluorescence lifetime, steady-state fluorescence emission intensity, and fluorescence anisotropy indicate that the anthraquinone ring partitions into the hydrophobic micelle interior. fluorescence quenching experiments using both steady-state and lifetime measurements demonstrate reduced accessibility of daunomycin in sodium dodecyl sulfate micelles to the anionic quencher iodide and to the neutral quencher acrylamide. quenching of daunomycin fluorescence by iodide in triton x-100 micelles was similar to that seen with free daunomycin. studies of the energetics of the interaction of daunomycin with micelles by fluorescence and absorbance titration methods and by isothermal titration calorimetry in the presence of excess micelles revealed that association with sodium dodecyl sulfate and triton x-100 micelles is driven by a large negative enthalpy. association of the drug with both types of micelles also has a favorable entropic contribution, which is larger in magnitude for triton x-100 micelles than for sodium dodecyl sulfate micelles. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000249838600033 |
| 公开日期 | 2010-07-13 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/14121]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Dignam JD,Qu XG,Ren JS,et al. Daunomycin binding to detergent micelles: A model system for evaluating the hydrophobic contribution to drug-DNA interactions[J]. journal of physical chemistry b,2007,111(39):11576-11584. |
| APA | Dignam JD,Qu XG,Ren JS,&Chaires JB.(2007).Daunomycin binding to detergent micelles: A model system for evaluating the hydrophobic contribution to drug-DNA interactions.journal of physical chemistry b,111(39),11576-11584. |
| MLA | Dignam JD,et al."Daunomycin binding to detergent micelles: A model system for evaluating the hydrophobic contribution to drug-DNA interactions".journal of physical chemistry b 111.39(2007):11576-11584. |
入库方式： OAI收割
来源：长春应用化学研究所
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