Metabolic profiling of serum from gadolinium chloride-treated rats by H-1 NMR spectroscopy
文献类型：期刊论文
| 作者 | Liao PQ ; Wei L ; Zhang XY ; Li XJ ; Wu HF ; Wu YJ ; Ni JZ ; Pei FK |
| 刊名 | analytical biochemistry
 |
| 出版日期 | 2007 |
| 卷号 | 364期号:2页码:112-121 |
| 关键词 | MAGNETIC-RESONANCE-SPECTROSCOPY PATTERN-RECOGNITION METHODS ALPHA-NAPHTHYLISOTHIOCYANATE NMR-SPECTROSCOPY URINE LIVER CLASSIFICATION PLASMA MOUSE LANTHANIDES |
| ISSN号 | 0003-2697 |
| 通讯作者 | li xj |
| 中文摘要 | metabolic profiling of serum from gadolinium chloride (gdcl3, 10 and 50 mg/kg body weight, intraperitoneal [i.p.])-treated rats was investigated by the nmr spectroscopic-based metabonomic strategy. serum samples were collected at 48, 96, and 168 h postdose (p.d.) after exposure to gdcl3. h-1 nmr spectra of serum were analyzed by pattern recognition using principal components analysis. the studies showed that there was a dose-related biochemical effect of gdcl3 treatment on the levels of a range of low-molecular weight compounds in serum. the liver damage induced by gdcl3 was characterized by the elevation of lactate, pyruvate, and creatine as well as the decrease of branched-chain amino acids (valine and isoleucine), alanine, glucose, and trimethylamine-n-oxide concentration in serum samples. the biochemical effects of gdcl3 in rats could be consulted when evaluating the biochemical profile of gadolinium-containing compounds that are being developed for nuclear magnetic resonance imaging. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000245960400003 |
| 公开日期 | 2010-07-13 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/14125]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Liao PQ,Wei L,Zhang XY,et al. Metabolic profiling of serum from gadolinium chloride-treated rats by H-1 NMR spectroscopy[J]. analytical biochemistry,2007,364(2):112-121. |
| APA | Liao PQ.,Wei L.,Zhang XY.,Li XJ.,Wu HF.,...&Pei FK.(2007).Metabolic profiling of serum from gadolinium chloride-treated rats by H-1 NMR spectroscopy.analytical biochemistry,364(2),112-121. |
| MLA | Liao PQ,et al."Metabolic profiling of serum from gadolinium chloride-treated rats by H-1 NMR spectroscopy".analytical biochemistry 364.2(2007):112-121. |
入库方式： OAI收割
来源：长春应用化学研究所
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