Mn(II)-monosubstituted polyoxometalates as candidates for contrast agents in magnetic resonance imaging
文献类型：期刊论文
| 作者 | Li ZF ; Li WS ; Li XJ ; Pei FK ; Wang XX ; Lei H |
| 刊名 | journal of inorganic biochemistry
 |
| 出版日期 | 2007 |
| 卷号 | 101期号:7页码:1036-1042 |
| ISSN号 | 0162-0134 |
| 关键词 | PRECLINICAL EVALUATION PROTON RELAXATION SERUM-ALBUMIN MRI COMPLEXES GADOLINIUM(III) WATER STABILITY GDDTPA METAL |
| 通讯作者 | li xj |
| 中文摘要 | two mono-substituted manganese polyoxometalates, k6mnsiw11o39 (mnsiw11) and k8mnp2w17o61 (mnp2w17), have been evaluated by in vivo and in vitro experiments as the candidates of potential tissue-specific contrast agents for magnetic resonance imaging (mri). t-1-relaxivities of 12.1 mm(-1) s(-1) for mnsiw11 and 4.7 mm(-1) s(-1) for mnp2w17 (400 mhz, 25 degrees c) were higher than or similar to that of the commercial mri contrast agent (gddtpa). their relaxivities in bsa and htf solutions were also reported. after administration of mnsiw11 and mnp2w17 to wistar rats, mr imaging showed longer and remarkable enhancement in rat liver and favorable renal excretion capability. the signal intensity increased by 74.0 +/- 4.9% for the liver during the whole imaging period (90 min) and by 67.2 +/- 5.3% for kidney within 20-70 min after injection at 40 +/- 3 mu mol kg(-1) dose for mnsiw11. mnp2w17 induced 71.5 +/- 15.1%. enhancement for the liver in 10-45 min range and 73.1 +/- 3.2% enhancement for kidney within 5-40 min after injection at 39 +/- 3 mu mol kg(-1) dose. in vitro and in vivo study showed mnsiw11 and mnp2w17 being favorable candidates as the tissue-specific contrast agents for mri. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000248109800008 |
| 公开日期 | 2010-07-13 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/14127]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Li ZF,Li WS,Li XJ,et al. Mn(II)-monosubstituted polyoxometalates as candidates for contrast agents in magnetic resonance imaging[J]. journal of inorganic biochemistry,2007,101(7):1036-1042. |
| APA | Li ZF,Li WS,Li XJ,Pei FK,Wang XX,&Lei H.(2007).Mn(II)-monosubstituted polyoxometalates as candidates for contrast agents in magnetic resonance imaging.journal of inorganic biochemistry,101(7),1036-1042. |
| MLA | Li ZF,et al."Mn(II)-monosubstituted polyoxometalates as candidates for contrast agents in magnetic resonance imaging".journal of inorganic biochemistry 101.7(2007):1036-1042. |
入库方式： OAI收割
来源：长春应用化学研究所
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