Direct formation of giant vesicles from synthetic polypeptides
文献类型：期刊论文
| 作者 | Sun J ; Chen XS ; Deng C ; Yu HJ ; Xie ZG ; Jing XB |
| 刊名 | langmuir
 |
| 出版日期 | 2007 |
| 卷号 | 23期号:16页码:8308-8315 |
| 关键词 | STIMULI-RESPONSIVE VESICLES BLOCK-COPOLYMERS DIBLOCK COPOLYMERS TRIBLOCK COPOLYMER BIOMIMETIC SYNTHESIS N-CARBOXYANHYDRIDES HOLLOW SPHERES PEPTIDE WATER POLYMERIZATION |
| ISSN号 | 0743-7463 |
| 通讯作者 | jing xb |
| 中文摘要 | this report describes direct formation of giant vesicles from a series of poly(l-lysine)-block-poly(l-phenylalanine) (pll-b-ppa) block copolymers from their water solution. these polymers are prepared by successive ring-opening polymerization (rop) of the two alpha-amino acid n-carboxyanhydrides and then removing the side chain protecting groups by acidolysis. the structures of the copolymers are confirmed by nuclear magnetic resonance (nmr), differential scanning calorimetry (dsc), and size exclusion chromatography ( sec). the vesicles are studied by atomic force microscopy (afm), field emission scanning electron microscopy (esem), and confocal laser scanning microscopy (clsm). rhodamine b is used as a fluorescent probe to confirm the existence of the vesicle with an aqueous interior. the vesicle size is in the range 0.55-6 mu m, depending on the absolute and relative lengths of the two blocks, on initial polymer concentration, and on solution ph. the vesicles are still stable in water for 2 months after preparation. addition of the copolymer to dna solution results in complex formation with it. the complex assumes the morphology of irregular particles of less than 2 mu m. it is expected to be used in drug and gene delivery. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000248229900007 |
| 公开日期 | 2010-07-13 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/14389]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Sun J,Chen XS,Deng C,et al. Direct formation of giant vesicles from synthetic polypeptides[J]. langmuir,2007,23(16):8308-8315. |
| APA | Sun J,Chen XS,Deng C,Yu HJ,Xie ZG,&Jing XB.(2007).Direct formation of giant vesicles from synthetic polypeptides.langmuir,23(16),8308-8315. |
| MLA | Sun J,et al."Direct formation of giant vesicles from synthetic polypeptides".langmuir 23.16(2007):8308-8315. |
入库方式： OAI收割
来源：长春应用化学研究所
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