RGD peptide grafted biodegradable amphiphilic triblock copolymer poly(glutamic acid)-b-poly(L-lactide)-b-poly(glutamic acid): Synthesis and self-assembly
文献类型：期刊论文
| 作者 | Deng C ; Chen XS ; Sun J ; Lu TC ; Wang WS ; Jing XB |
| 刊名 | journal of polymer science part a-polymer chemistry
 |
| 出版日期 | 2007 |
| 卷号 | 45期号:15页码:3218-3230 |
| ISSN号 | 0887-624x |
| 关键词 | BLOCK-COPOLYMER POLY(GAMMA-BENZYL L-GLUTAMATE) BIOMEDICAL APPLICATIONS DIBLOCK COPOLYMERS AQUEOUS-MEDIUM POLYMERS MICELLES HYDROGELS SURGERY CORE |
| 通讯作者 | jing xb |
| 中文摘要 | a novel amphiphilic biodegradable triblock copolymer (pgl-pla-pgl) with polylactide (pla) as hydrophobic middle block and poly(glutamic acid) (pgl) as hydrophilic lateral blocks was successfully synthesized by ring-opening polymerization (rop) of l-lactide (la) and n-carboxy anhydride (nca) consecutively and by subsequent catalytic hydrogenation. the results of cell experiment of pgl-pla-pgl suggested that pgl could improve biocompatibility of polyester obviously. the copolymer could form micelles of spindly shape easily in aqueous solution. the pendant carboxyl groups of the triblock copolymer were further activated with n-hydroxysuccinimide and combined with a cell-adhesive peptide grgi)sy incorporation of the oligopeptide further enhanced the hydrophilicity and led to formation of spherical micelles. pgl-plapgl showed better cell adhesion and spreading ability than pure pla and the grgdsy-containing copolymer exhibited even further improvement in cell adhesion and spreading ability, indicating that the copolymer could find a promising application in drug delivery or tissue engineering. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000248021700007 |
| 公开日期 | 2010-07-13 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/14393]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Deng C,Chen XS,Sun J,et al. RGD peptide grafted biodegradable amphiphilic triblock copolymer poly(glutamic acid)-b-poly(L-lactide)-b-poly(glutamic acid): Synthesis and self-assembly[J]. journal of polymer science part a-polymer chemistry,2007,45(15):3218-3230. |
| APA | Deng C,Chen XS,Sun J,Lu TC,Wang WS,&Jing XB.(2007).RGD peptide grafted biodegradable amphiphilic triblock copolymer poly(glutamic acid)-b-poly(L-lactide)-b-poly(glutamic acid): Synthesis and self-assembly.journal of polymer science part a-polymer chemistry,45(15),3218-3230. |
| MLA | Deng C,et al."RGD peptide grafted biodegradable amphiphilic triblock copolymer poly(glutamic acid)-b-poly(L-lactide)-b-poly(glutamic acid): Synthesis and self-assembly".journal of polymer science part a-polymer chemistry 45.15(2007):3218-3230. |
入库方式： OAI收割
来源：长春应用化学研究所
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