Triblock poly(lactic acid)-b-poly(ethylene glycol)-b-poly(lactic acid)/paclitaxel conjugates: Synthesis, micellization, and cytotoxicity
文献类型：期刊论文
| 作者 | Xie ZG ; Lu TC ; Chen XS ; Lu CH ; Zheng YH ; Jing XB |
| 刊名 | journal of applied polymer science
 |
| 出版日期 | 2007 |
| 卷号 | 105期号:4页码:2271-2279 |
| ISSN号 | 0021-8995 |
| 关键词 | POLYETHYLENE-GLYCOL DELIVERY-SYSTEMS OVARIAN-CANCER IN-VITRO PACLITAXEL TAXOL NANOPARTICLES COPOLYMERS TUMORS CHEMOTHERAPY |
| 通讯作者 | jing xb |
| 中文摘要 | a triblock poly(lactic acid)-b-poly(ethylene glycol)-b-poly(lactic acid) (pla-peg-pla)/paclitaxel (ptx) conjugate was synthesized by the reaction of carboxyl-terminated copolymer pla-peg-pla with ptx in the presence of dicyclohexylcarbodiimide and dimethylaminopyridine. carboxyl-terminated copolymer pla-peg-pla was prepared by the reaction of the hydroxyl end groups in copolymer pla-peg-pla with succinic anhydride. its structure was confirmed by nmr and gel permeation chromatography. the pla-peg-pla/ptx conjugates could self-assemble into micelles in aqueous solutions with a low critical micelle concentration. dynamic light scattering and environmental scanning electron microscopy analyses of the pla-peg-pla/ptx micelles revealed their spherical structure and size of 220 nm. the antitumor activity of the conjugate against woman hela cancer cells, evaluated by the 3-(4,5-dimethylthiazol2-yl)-2,5-diphenyl tetrazolium bromide method, showed that the conjugates had an antitumor activity similar to that of pure ptx. the obtained pla-peg-pla/ptx conjugates are expected to be used in clinical practice. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000247576600069 |
| 公开日期 | 2010-07-13 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/14401]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xie ZG,Lu TC,Chen XS,et al. Triblock poly(lactic acid)-b-poly(ethylene glycol)-b-poly(lactic acid)/paclitaxel conjugates: Synthesis, micellization, and cytotoxicity[J]. journal of applied polymer science,2007,105(4):2271-2279. |
| APA | Xie ZG,Lu TC,Chen XS,Lu CH,Zheng YH,&Jing XB.(2007).Triblock poly(lactic acid)-b-poly(ethylene glycol)-b-poly(lactic acid)/paclitaxel conjugates: Synthesis, micellization, and cytotoxicity.journal of applied polymer science,105(4),2271-2279. |
| MLA | Xie ZG,et al."Triblock poly(lactic acid)-b-poly(ethylene glycol)-b-poly(lactic acid)/paclitaxel conjugates: Synthesis, micellization, and cytotoxicity".journal of applied polymer science 105.4(2007):2271-2279. |
入库方式： OAI收割
来源：长春应用化学研究所
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