Enantiomeric PLA-PEG block copolymers and their stereocomplex micelles used as rifampin delivery
文献类型：期刊论文
| 作者 | Chen L ; Xie ZG ; Hu JL ; Chen XS ; Jing XB |
| 刊名 | journal of nanoparticle research
 |
| 出版日期 | 2007 |
| 卷号 | 9期号:5页码:777-785 |
| ISSN号 | 1388-0764 |
| 关键词 | DRUG-DELIVERY TRIBLOCK COPOLYMERS STEREOSELECTIVE POLYMERIZATION POLY(ETHYLENE GLYCOL) BASE COMPLEX RAC-LACTIDE SYSTEMS DESIGN TUMOR WATER |
| 通讯作者 | chen xs |
| 中文摘要 | a novelty approach to self-assembling stereocomplex micelles by enantiomeric pla-peg block copolymers as a drug delivery carrier was described. the particles were encapsulated by enantiomeric pla-peg stereocomplex to form nanoscale micelles different from the microspheres or the single micelles by plla or pdla in the reported literatures. first, the block copolymers of enantiomeric poly(l-lactide)-poly(ethylene-glycol) (plla-peg) and poly(d-lactide)-poly(ethylene-glycol) (pdla-peg) were synthesized by the ring-opening polymerization of l-lactide and d-lactide in the presence of monomethoxy peg, respectively. second, the stereocomplex block copolymer micelles were obtained by the self-assembly of the equimolar mixtures of enantiomeric pla-peg copolymers in water. these micelles possessed partially the crystallized hydrophobic cores with the critical micelle concentrations (cmc) in the range of 0.8-4.8 mg/l and the mean hydrodynamic diameters ranging from 40 to 120 nm. the micelle sizes and cmc values obviously depended on the hydrophobic block pla content in the copolymer.compared with the single plla-peg or pdla peg micelles, the cmc values of the stereocomplex micelles became lower and the sizes of the stereocomplex micelles formed smaller. and lastly, the stereocomplex micelles encapsulated with rifampin were tested for the controlled release application. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000247471500007 |
| 公开日期 | 2010-07-13 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/14405]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Chen L,Xie ZG,Hu JL,et al. Enantiomeric PLA-PEG block copolymers and their stereocomplex micelles used as rifampin delivery[J]. journal of nanoparticle research,2007,9(5):777-785. |
| APA | Chen L,Xie ZG,Hu JL,Chen XS,&Jing XB.(2007).Enantiomeric PLA-PEG block copolymers and their stereocomplex micelles used as rifampin delivery.journal of nanoparticle research,9(5),777-785. |
| MLA | Chen L,et al."Enantiomeric PLA-PEG block copolymers and their stereocomplex micelles used as rifampin delivery".journal of nanoparticle research 9.5(2007):777-785. |
入库方式： OAI收割
来源：长春应用化学研究所
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