A biodegradable triblock copolymer poly(ethylene glycol)-b-poly(L-lactide)-b-poly(L-lysine): Synthesis, self-assembly and RGD peptide modification
文献类型：期刊论文
| 作者 | Deng C ; Chen XS ; Yu HJ ; Sun J ; Lu TC ; Jing XB |
| 刊名 | polymer
 |
| 出版日期 | 2007 |
| 卷号 | 48期号:1页码:139-149 |
| 关键词 | ACID) BLOCK-COPOLYMER CELL-ADHESION POLY(GAMMA-BENZYL L-GLUTAMATE) N-CARBOXYANHYDRIDES AQUEOUS-MEDIUM DRUG-DELIVERY POLYMERS MICELLES POLYURETHANE HYDROGELS |
| ISSN号 | 0032-3861 |
| 通讯作者 | jing xb |
| 中文摘要 | a novel biodegradable triblock copolymer poly(ethylene glycol)-b-poly(l-lactide)-b-poly(l-lysine) (peg-pla-pll) was synthesized by acidolysis of poly(ethylene glycol)-b-poly(l-lactide)-b-poly(f-benzyloxycarbonyl-l-lysine) (peg-pla-pzll) obtained by the ring-opening polymerization (rop) of epsilon-benzyloxycarbonyl-l-lysine n-carboxyanhydride (zlys nca) with amino-terminated peg-pla-nh2 as a macro-initiator, and the pendant amino groups of the lysine residues were modified with a peptide known to modulate cellular functions, gly-arg-gly-asp-ser-tyr (grgdsy, abbreviated as rgd) in the presence of 1,1'-carbonyldiimidazole (cdi). the structures of peg-pla-pll/rgd and its precursors were confirmed by h-1 nmr, ft-ir, amino acid analysis and xps analysis. the cell adhesion and cell spread on the peg-pla-pll/rgd film were enhanced compared to those on pure pla film. therefore, the novel rgd-grafted triblock copolymer is promising for cell or tissue engineering applications. both copolymers peg-pla-pzll and peg-pla-pll showed an amphiphilic nature and could self-assemble into micelles of homogeneous spherical morphology. the micelles were determined by fluorescence technique, dynamic light scattering (dls), and field emission scanning electron microscopy (esem) and could be expected to find application in drug and gene delivery systems. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000245337500018 |
| 公开日期 | 2010-07-13 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/14429]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Deng C,Chen XS,Yu HJ,et al. A biodegradable triblock copolymer poly(ethylene glycol)-b-poly(L-lactide)-b-poly(L-lysine): Synthesis, self-assembly and RGD peptide modification[J]. polymer,2007,48(1):139-149. |
| APA | Deng C,Chen XS,Yu HJ,Sun J,Lu TC,&Jing XB.(2007).A biodegradable triblock copolymer poly(ethylene glycol)-b-poly(L-lactide)-b-poly(L-lysine): Synthesis, self-assembly and RGD peptide modification.polymer,48(1),139-149. |
| MLA | Deng C,et al."A biodegradable triblock copolymer poly(ethylene glycol)-b-poly(L-lactide)-b-poly(L-lysine): Synthesis, self-assembly and RGD peptide modification".polymer 48.1(2007):139-149. |
入库方式： OAI收割
来源：长春应用化学研究所
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