Synthesis and characterization of photo-cross-linked hydrogels based on biodegradable polyphosphoesters and poly(ethylene glycol) copolymers
文献类型：期刊论文
| 作者 | Du JZ ; Sun TM ; Weng SQ ; Chen XS ; Wang J |
| 刊名 | biomacromolecules
 |
| 出版日期 | 2007 |
| 卷号 | 8期号:11页码:3375-3381 |
| 关键词 | RING-OPENING POLYMERIZATION IN-VITRO BLOCK-COPOLYMERS DELIVERY SYSTEMS DRUG-DELIVERY NETWORKS BIONANOTECHNOLOGY CYTOCOMPATIBILITY POLYESTER MEDICINE |
| ISSN号 | 1525-7797 |
| 通讯作者 | wang j |
| 中文摘要 | novel biodegradable hydrogels by photo-cross-linking macromers based on polyphosphoesters and poly(ethylene glycol) (peg) are reported. photo-cross-linkable macromers were synthesized by ring-opening polymerization of the cyclic phosphoester monomer 2-(2-oxo-1,3,2-dioxaphospholoyloxy) ethyl methacrylate (opema) using peg as the initiator and stannous octoate as the catalyst. the macrorners were characterized by h-1 nmr, fourier transform infrared spectroscopy, and gel permeation chromatography measurements. the content of polyphosphoester in the macromer was controlled by varying the feed ratio of opema to peg. hydrogels were fabricated by exposing aqueous solutions of macromers with 0.05% (w/w) photoinitiator to uv light irradiation, and their swelling kinetics as well as degradation behaviors were evaluated. the results demonstrated that cross-linking density and ph values strongly affected the degradation rates. the macromers was compatible to osteoblast cells, not exhibiting significant cytotoxicity up to 0.5 mg/ml. "live/dead" cell staining assay also demonstrated that a large majority of the osteoblast cells remained viable after encapsulation into the hydrogel constructs, showing their potential as tissue engineering scaffolds. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000250960300013 |
| 公开日期 | 2010-07-13 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/14689]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Du JZ,Sun TM,Weng SQ,et al. Synthesis and characterization of photo-cross-linked hydrogels based on biodegradable polyphosphoesters and poly(ethylene glycol) copolymers[J]. biomacromolecules,2007,8(11):3375-3381. |
| APA | Du JZ,Sun TM,Weng SQ,Chen XS,&Wang J.(2007).Synthesis and characterization of photo-cross-linked hydrogels based on biodegradable polyphosphoesters and poly(ethylene glycol) copolymers.biomacromolecules,8(11),3375-3381. |
| MLA | Du JZ,et al."Synthesis and characterization of photo-cross-linked hydrogels based on biodegradable polyphosphoesters and poly(ethylene glycol) copolymers".biomacromolecules 8.11(2007):3375-3381. |
入库方式： OAI收割
来源：长春应用化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。