Downhill kinetics of biomolecular interface binding: Globally connected scenario
文献类型：期刊论文
| 作者 | Wang J ; Huang WM ; Lu HY ; Wang EK |
| 刊名 | biophysical journal
 |
| 出版日期 | 2004 |
| 卷号 | 87期号:4页码:2187-2194 |
| 关键词 | PROTEIN-FOLDING KINETICS MOLECULE DYNAMICS PHOTON ROUGH ENERGY LANDSCAPES SINGLE-MOLECULE HEME-PROTEINS COMBINATORIAL TECHNOLOGIES STRUCTURAL DYNAMICS ENZYMATIC DYNAMICS DRUG DISCOVERY LIGAND-BINDING |
| ISSN号 | 0006-3495 |
| 通讯作者 | wang j |
| 中文摘要 | we study the kinetics of the biomolecular binding process at the interface using energy landscape theory. the global kinetic connectivity case is considered for a downhill funneled energy landscape. by solving the kinetic master equation, the kinetic time for binding is obtained and shown to have a u-shape curve-dependence on the temperature. the kinetic minimum of the binding time monotonically decreases when the ratio of the underlying energy gap between native state and average non-native states versus the roughness or the fluctuations of the landscape increases. at intermediate temperatures,fluctuations measured by the higher moments of the binding time lead to non-poissonian, non-exponential kinetics. at both high and very low temperatures, the kinetics is nearly poissonian and exponential. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000224129200008 |
| 公开日期 | 2010-08-17 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/14797]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wang J,Huang WM,Lu HY,et al. Downhill kinetics of biomolecular interface binding: Globally connected scenario[J]. biophysical journal,2004,87(4):2187-2194. |
| APA | Wang J,Huang WM,Lu HY,&Wang EK.(2004).Downhill kinetics of biomolecular interface binding: Globally connected scenario.biophysical journal,87(4),2187-2194. |
| MLA | Wang J,et al."Downhill kinetics of biomolecular interface binding: Globally connected scenario".biophysical journal 87.4(2004):2187-2194. |
入库方式： OAI收割
来源：长春应用化学研究所
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