Characterization of non-covalent complexes of rutin with cyclodextrins by electrospray ionization tandem mass spectrometry
文献类型：期刊论文
| 作者 | Guo MQ ; Song FR ; Liu ZQ ; Liu SY |
| 刊名 | journal of mass spectrometry
 |
| 出版日期 | 2004 |
| 卷号 | 39期号:6页码:594-599 |
| 关键词 | COLLISION-INDUCED DISSOCIATION FAST-ATOM-BOMBARDMENT BETA-CYCLODEXTRIN CHEMISTRY |
| ISSN号 | 1076-5174 |
| 通讯作者 | liu zq |
| 中文摘要 | electrospray ionization tandem mass spectrometry (esi-msn) and the phase solubility method were used to characterize the gas-phase and solution-phase non-covalent complexes between rutin (r) and alpha-, beta- and gamma-cyclodextrins (cds). the direct correlation between mass spectrometric results and solution-phase behavior is thus revealed. the order of the 1:1 association constants (k-c) of the complexes between r and the three cds in solution calculated from solubility diagrams is in good agreement with the order of their relative peak intensities and relative collision-induced dissociation (cid) energies of the complexes under the same esi-msn condition in both the positive and negative ion modes. not only the binding stoichiometry but also the relative stabilities and even binding sites of the cd-r complexes can be elucidated by esi-msn. the diagnostic fragmentation of cd-r complexes, with a significant contribution of covalent fragmentation of rutin leaving the quercetin (q) moiety attached to the cds, provides convincing evidence for the formation of inclusion complexes between r and cds. the diagnostic fragment ions can be partly confirmed by the complexes between q and cds. the gas-phase stability order of the deprotonated cd-r complexes is beta-cd-r > alpha-cd-r > gamma-cd/r; beta-cd seems to bind r more strongly than the other cds. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000222340600002 |
| 公开日期 | 2010-08-17 |
| 源URL | [http://202.98.16.49/handle/322003/15455]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Guo MQ,Song FR,Liu ZQ,et al. Characterization of non-covalent complexes of rutin with cyclodextrins by electrospray ionization tandem mass spectrometry[J]. journal of mass spectrometry,2004,39(6):594-599. |
| APA | Guo MQ,Song FR,Liu ZQ,&Liu SY.(2004).Characterization of non-covalent complexes of rutin with cyclodextrins by electrospray ionization tandem mass spectrometry.journal of mass spectrometry,39(6),594-599. |
| MLA | Guo MQ,et al."Characterization of non-covalent complexes of rutin with cyclodextrins by electrospray ionization tandem mass spectrometry".journal of mass spectrometry 39.6(2004):594-599. |
入库方式： OAI收割
来源：长春应用化学研究所
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