Investigation of sandwiched gadolinium(III) complexes with tungstosilicates as potential MRI contrast agents
文献类型：期刊论文
| 作者 | Sun GY ; Feng JH ; Wu HF ; Pei FK ; Fang K ; Lei H |
| 刊名 | magnetic resonance imaging
 |
| 出版日期 | 2004 |
| 卷号 | 22期号:3页码:421-426 |
| 关键词 | RELAXATION WATER QUALITY GDDTPA |
| ISSN号 | 0730-725x |
| 通讯作者 | pei fk |
| 中文摘要 | two gadolinium-sandwiched complexes with tungstosilicates, k-13[gd(siw11o39)(2)] (gd(siw11)(2)) and k11h6[gd2o3(siw9o34)(2)] (gd-3(siw9)(2)), have been investigated by in vitro and in vivo experiments as potential contrast agents for magnetic resonance imaging (mri). t-1-relaxivity of gd(siw11)(2)was 6.59 mm(-1) . s(-1) in aqueous solution and 6.85 mm(-1) . s(-1) in 0.725 mmol . l-1 bovine serum albumin solution at 25degreesc and 9.39 t, respectively. the corresponding t-1-relaxivity of gd-3(siw9)(2) was 12.6 and 19.3 mm(-1) . s(-1) per gd, respectively. mri for sprague-dawley rats showed longer and more remarkable enhancement in rat liver after i.v. injection of these two complexes: 39.4 +/- 3.9% and 57.4 +/- 11.6% within the first 30 min after injection, 31.2 +/- 2.6% and 39.9 +/- 7.6% in the next 60 min for gd(siw11)(2) and gd-3(siw9)(2) at doses of 0.081 and 0.084 mmol gd/kg, respectively. our preliminary in vitro and in vivo study indicates that gd(siw11)(2) and gd-3(siw9)(2) are favorable candidates for hepatic contrast agents for mri. however, the two complexes exhibit higher acute toxicity and need to be modified and studied further before clinical use. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000220946900016 |
| 公开日期 | 2010-08-17 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/15657]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Sun GY,Feng JH,Wu HF,et al. Investigation of sandwiched gadolinium(III) complexes with tungstosilicates as potential MRI contrast agents[J]. magnetic resonance imaging,2004,22(3):421-426. |
| APA | Sun GY,Feng JH,Wu HF,Pei FK,Fang K,&Lei H.(2004).Investigation of sandwiched gadolinium(III) complexes with tungstosilicates as potential MRI contrast agents.magnetic resonance imaging,22(3),421-426. |
| MLA | Sun GY,et al."Investigation of sandwiched gadolinium(III) complexes with tungstosilicates as potential MRI contrast agents".magnetic resonance imaging 22.3(2004):421-426. |
入库方式： OAI收割
来源：长春应用化学研究所
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