Gadolinium heteropoly complex K-17[Gd(P2W17O61)(2)] as a potential MRI contrast agent
文献类型：期刊论文
| 作者 | Sun GY ; Feng JH ; Wu HF ; Pei FK ; Fang K ; Lei H |
| 刊名 | journal of magnetism and magnetic materials
 |
| 出版日期 | 2004 |
| 卷号 | 281期号:2-3页码:405-409 |
| 关键词 | HUMAN SERUM-ALBUMIN RELAXATION CHELATE GDDTPA DTPA |
| ISSN号 | 0304-8853 |
| 通讯作者 | pei fk |
| 中文摘要 | gadolinium heteropoly complex k-17[gd(p2w17o61)(2)] has been evaluated by in vitro and in vivo experiments as a potential contrast agent for magnetic resonance imaging (mri). the thermal analysis and conductivity study indicate that this complex has good thermal stability and wide ph stability range. the t-1 relaxivity is 7.59 mm(-1) s(-1) in aqueous solution and 7.97 mm(-1) s(-1) in 0.725 mmol l(-1) bovine serum albumin (bsa) solution at 25degreesc and 9.39 t, respectively. mr imaging of three male sprague-dawley rats showed remarkable enhancement in rat liver after intravenous injection, which persisted longer than with gd-dtpa. the signal intensity increased by 57.1 +/- 16.9% during the whole imaging period at 0.082 mmol kg(-1) dose. our preliminary in vitro and in vivo studies indicate that k-17[gd(p2w17o61)(2)] is a potential liver-specific mri contrast agent. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000224236200037 |
| 公开日期 | 2010-08-17 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/15661]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Sun GY,Feng JH,Wu HF,et al. Gadolinium heteropoly complex K-17[Gd(P2W17O61)(2)] as a potential MRI contrast agent[J]. journal of magnetism and magnetic materials,2004,281(2-3):405-409. |
| APA | Sun GY,Feng JH,Wu HF,Pei FK,Fang K,&Lei H.(2004).Gadolinium heteropoly complex K-17[Gd(P2W17O61)(2)] as a potential MRI contrast agent.journal of magnetism and magnetic materials,281(2-3),405-409. |
| MLA | Sun GY,et al."Gadolinium heteropoly complex K-17[Gd(P2W17O61)(2)] as a potential MRI contrast agent".journal of magnetism and magnetic materials 281.2-3(2004):405-409. |
入库方式： OAI收割
来源：长春应用化学研究所
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