Structural selectivity of aromatic diamidines
文献类型：期刊论文
| 作者 | Chaires JB ; Ren J ; Hamelberg D ; Kumar A ; Pandya V ; Boykin DW ; Wilson WD |
| 刊名 | journal of medicinal chemistry
 |
| 出版日期 | 2004 |
| 卷号 | 47期号:23页码:5729-5742 |
| 关键词 | DNA MINOR-GROOVE ANTIPROTOZOAL ACTIVITY CRYSTAL-STRUCTURES NUCLEIC-ACIDS SEQUENCE BINDING LIGANDS COMPLEXES AFFINITY CATIONS |
| ISSN号 | 0022-2623 |
| 通讯作者 | chaires jb |
| 中文摘要 | competition dialysis was used to study the interactions of 13 substituted aromatic diamidine compounds with 13 nucleic acid structures and sequences. the results show a striking selectivity of these compounds for the triplex structure poly da:(poly dt)(2), a novel aspect of their interaction with nucleic acids not previously described. the triplex selectivity of selected compounds was confirmed by thermal denaturation studies. triplex selectivity was found to be modulated by the location of amidine substiuents on the core phenyl-furan-phenyl ring scaffold. molecular models were constructed to rationalize the triplex selectivity of db359, the most selective compound in the series. its triplex selectivity was found to arise from optimal ring stacking on base triplets, along with proper positioning of its amidine substituents to occupy the minor and the major-minor grooves of the triplex. new insights into the molecular recognition of nucleic acid structures emerged from these studies, adding to the list of available design principles for selectively targeting dna and rna. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000224841600019 |
| 公开日期 | 2010-08-17 |
| 源URL | [http://202.98.16.49/handle/322003/15677]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Chaires JB,Ren J,Hamelberg D,et al. Structural selectivity of aromatic diamidines[J]. journal of medicinal chemistry,2004,47(23):5729-5742. |
| APA | Chaires JB.,Ren J.,Hamelberg D.,Kumar A.,Pandya V.,...&Wilson WD.(2004).Structural selectivity of aromatic diamidines.journal of medicinal chemistry,47(23),5729-5742. |
| MLA | Chaires JB,et al."Structural selectivity of aromatic diamidines".journal of medicinal chemistry 47.23(2004):5729-5742. |
入库方式： OAI收割
来源：长春应用化学研究所
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