Synthesis and characterization of the paclitaxel/MPEG-PLA block copolymer conjugate
文献类型：期刊论文
| 作者 | Zhang XF ; Li YX ; Chen XS ; Wang XH ; Xu XY ; Liang QZ ; Hu JL ; Jing XB |
| 刊名 | biomaterials
 |
| 出版日期 | 2005 |
| 卷号 | 26期号:14页码:2121-2128 |
| 关键词 | WATER-SOLUBLE PRODRUGS ANTITUMOR-ACTIVITY POLY(ETHYLENE GLYCOL) IN-VIVO TAXOL FORMULATIONS DELIVERY NANOPARTICLES MICROSPHERES NANOSPHERES |
| ISSN号 | 0142-9612 |
| 通讯作者 | jing xb |
| 中文摘要 | a paclitaxel/mpeg-pla block copolymer conjugate was prepared in three steps: (1) hydroxyl-terminated diblock copolymer of monomethoxy-poly(ethylene glycol)-b-poly(lactide) (mpeg-pla) was synthesized by ring-opening polymerization of l-lactide using mpeg as a maroinitiator, (2) it was converted to carboxyl-terminated mpeg-pla by reacting with mono-i-butyl ester of diglycolic acid and subsequent deprotecting the t-butyl group with tfa; (3) the latter was reacted with paclitaxel in the presence of dicyclohexylcarbodiimide and dimethylaminopyridine. structures of the polymers synthesized were confirmed by h-1 nmr, and their molecular weights were determined by gel permeation chromatography. the antitumor activity of the conjugate against human liver cancer h7402 cells was evaluated by mtt method. the results showed that paclitaxel can be released from the conjugate without losing cytotoxicity. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000226663800054 |
| 公开日期 | 2010-08-17 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/15703]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhang XF,Li YX,Chen XS,et al. Synthesis and characterization of the paclitaxel/MPEG-PLA block copolymer conjugate[J]. biomaterials,2005,26(14):2121-2128. |
| APA | Zhang XF.,Li YX.,Chen XS.,Wang XH.,Xu XY.,...&Jing XB.(2005).Synthesis and characterization of the paclitaxel/MPEG-PLA block copolymer conjugate.biomaterials,26(14),2121-2128. |
| MLA | Zhang XF,et al."Synthesis and characterization of the paclitaxel/MPEG-PLA block copolymer conjugate".biomaterials 26.14(2005):2121-2128. |
入库方式： OAI收割
来源：长春应用化学研究所
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