The antioxidative effect of icariin in human erythrocytes against free-radical-induced haemolysis
文献类型：期刊论文
| 作者 | Liu ZQ ; Luo XY ; Sun YX ; Wu W ; Liu CM ; Liu ZQ ; Liu SY |
| 刊名 | journal of pharmacy and pharmacology
 |
| 出版日期 | 2004 |
| 卷号 | 56期号:12页码:1557-1562 |
| 关键词 | RED-BLOOD-CELLS IN-VITRO DERIVATIVES INHIBITION CHROMONES OXIDATION COUMARIN |
| ISSN号 | 0022-3573 |
| 通讯作者 | liu zq |
| 中文摘要 | icariin (2-(4'-methoxyl phenyl)-3-rhamnosido-5-hydroxyl-7-glucosido-8-(3'-methyl-2-butyleny"chromanone) is the major component in herba epimedii used in traditional chinese medicine for the treatment of atherosclerosis. this work focuses on the antioxidative effect of icariin on freeradical-induced haemolysis of human erythrocytes, in which the initial free radical derives from the decomposition of 2,2'-azobis(2-amidinopropane hydrochloride) (aaph) at physiological temperature. to reveal the structure-activity relationship of icariin, the antioxidant effects of two structural analogues of icariin, acacetin (2-(4'-methoxylphenyl)-5,7-dihydroxylchromone) and norwogonin (2-phenyl-5,7,8-trihydroxylchromone), on the same experimental system were examined as well. it was found that all these chromone derivatives (chm-ohs) dose-dependently protected human erythrocytes against free-radical-induced haemolysis. the order of antioxidative activity was nonvogoni-n > acacetin > icariin by the analysis of the relationship between the concentration of chm-ohs and the prolongation percentage of the lag time of haemolysis (pp%). it was also proved that the phenyl hydroxyl group attached to the chromone ring at 7-position cannot trap the free radical- on the contrary, phenyl hydroxyl groups at the 5- and 8-position in nonvogonin made it a significant antioxidant in aaph-induced haemolysis. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000225815200010 |
| 公开日期 | 2010-08-17 |
| 源URL | [http://202.98.16.49/handle/322003/15829]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Liu ZQ,Luo XY,Sun YX,et al. The antioxidative effect of icariin in human erythrocytes against free-radical-induced haemolysis[J]. journal of pharmacy and pharmacology,2004,56(12):1557-1562. |
| APA | Liu ZQ.,Luo XY.,Sun YX.,Wu W.,Liu CM.,...&Liu SY.(2004).The antioxidative effect of icariin in human erythrocytes against free-radical-induced haemolysis.journal of pharmacy and pharmacology,56(12),1557-1562. |
| MLA | Liu ZQ,et al."The antioxidative effect of icariin in human erythrocytes against free-radical-induced haemolysis".journal of pharmacy and pharmacology 56.12(2004):1557-1562. |
入库方式： OAI收割
来源：长春应用化学研究所
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