Carboxyl-modified single-walled carbon nanotubes selectively induce human telomeric i-motif formation
文献类型：期刊论文
| 作者 | Li X ; Peng YH ; Ren JS ; Qu XG |
| 刊名 | proceedings of the national academy of sciences of the united states of america
 |
| 出版日期 | 2006 |
| 卷号 | 103期号:52页码:19658-19663 |
| 关键词 | NUCLEIC-ACIDS G-QUADRUPLEX DNA COMPLEX BINDING TRANSITION TETRAPLEX SEQUENCE EUROPIUM DUPLEX |
| ISSN号 | 0027-8424 |
| 通讯作者 | qu xg |
| 中文摘要 | as the leading nanodevice candidate, single-walled carbon nano-tubes (swnts) have potential therapeutic applications in gene therapy and novel drug delivery. we found that swnts can inhibit dna duplex association and selectively induce human telomeric i-motif dna formation by binding to the 5'-end major groove under physiological conditions or even at ph 8.0. swnt binding to telomeric dna was studied by uv melting, nmr, s1 nuclease cleavage, cd, and competitive fret methods. these results suggest that swnts might have the intriguing potential to modulate human telomeric dna structures in vivo, like biologically relevant b-a and b-z dna transitions, which is of great interest for drug design and cancer therapy. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000243285500011 |
| 公开日期 | 2010-08-17 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/15843]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Li X,Peng YH,Ren JS,et al. Carboxyl-modified single-walled carbon nanotubes selectively induce human telomeric i-motif formation[J]. proceedings of the national academy of sciences of the united states of america,2006,103(52):19658-19663. |
| APA | Li X,Peng YH,Ren JS,&Qu XG.(2006).Carboxyl-modified single-walled carbon nanotubes selectively induce human telomeric i-motif formation.proceedings of the national academy of sciences of the united states of america,103(52),19658-19663. |
| MLA | Li X,et al."Carboxyl-modified single-walled carbon nanotubes selectively induce human telomeric i-motif formation".proceedings of the national academy of sciences of the united states of america 103.52(2006):19658-19663. |
入库方式： OAI收割
来源：长春应用化学研究所
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