Carbon nanotubes selective destabilization of duplex and triplex DNA and inducing B-A transition in solution
文献类型：期刊论文
| 作者 | Li X ; Peng YH ; Qu XG |
| 刊名 | nucleic acids research
 |
| 出版日期 | 2006 |
| 卷号 | 34期号:13页码:3670-3676 |
| 关键词 | FLOW LINEAR DICHROISM CIRCULAR-DICHROISM BINDING SEQUENCE CONDENSATION POLYMORPHISM RECOGNITION NEOMYCIN AGENTS FORM |
| ISSN号 | 0305-1048 |
| 通讯作者 | qu xg |
| 中文摘要 | single-walled carbon nanotubes (swnts) have been considered as the leading candidate for nano-device applications ranging from gene therapy and novel drug delivery to membrane separations. the miniaturization of dna-nanotube devices for biological applications requires fully understanding dna-nanotube interaction mechanism. we report here, for the first time, that dna destabilization and conformational transition induced by swnts are sequence-dependent. contrasting changes for swnts binding to poly[dgdc]:poly[dgdc] and poly[dadt]:poly[dadt] were observed. for gc homopolymer, dna melting temperature was decreased 40 degrees c by swnts but no change for at-dna. swnts can induce b-a transition for gc-dna but at-dna resisted the transition. our circular dichroism, competitive binding assay and triplex destabilization studies provide direct evidence that swnts induce dna b-a transition in solution and they bind to the dna major groove with gc preference. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000240583100017 |
| 公开日期 | 2010-08-17 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/15849]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Li X,Peng YH,Qu XG. Carbon nanotubes selective destabilization of duplex and triplex DNA and inducing B-A transition in solution[J]. nucleic acids research,2006,34(13):3670-3676. |
| APA | Li X,Peng YH,&Qu XG.(2006).Carbon nanotubes selective destabilization of duplex and triplex DNA and inducing B-A transition in solution.nucleic acids research,34(13),3670-3676. |
| MLA | Li X,et al."Carbon nanotubes selective destabilization of duplex and triplex DNA and inducing B-A transition in solution".nucleic acids research 34.13(2006):3670-3676. |
入库方式： OAI收割
来源：长春应用化学研究所
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