Dominant kinetic paths on biomolecular binding-folding energy landscape
文献类型：期刊论文
| 作者 | Wang J ; Zhang K ; Lu HY ; Wang EK |
| 刊名 | physical review letters
 |
| 出版日期 | 2006 |
| 卷号 | 96期号:16页码:文献编号：168101 |
| 关键词 | MOLECULAR RECOGNITION INTEGRAL SOLUTIONS TRANSITION-STATE PROTEIN FUNCTION SINGLE-MOLECULE TEMPERATURE DYNAMICS TRAJECTORIES SPECIFICITY MECHANISM |
| ISSN号 | 0031-9007 |
| 通讯作者 | wang j |
| 中文摘要 | the identification of kinetic pathways is a central issue in understanding the nature of flexible binding. a new approach is proposed here to study the dynamics of this binding-folding process through the establishment of a path integral framework on the underlying energy landscape. the dominant kinetic paths of binding and folding can be determined and quantified. in this case, the corresponding kinetic paths of binding are shown to be intimately correlated with those of folding and the dynamics becomes quite cooperative. the kinetic time can be obtained through the contributions from the dominant paths and has a u-shape dependence on temperature. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000237156700073 |
| 公开日期 | 2010-08-17 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/15851]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wang J,Zhang K,Lu HY,et al. Dominant kinetic paths on biomolecular binding-folding energy landscape[J]. physical review letters,2006,96(16):文献编号：168101. |
| APA | Wang J,Zhang K,Lu HY,&Wang EK.(2006).Dominant kinetic paths on biomolecular binding-folding energy landscape.physical review letters,96(16),文献编号：168101. |
| MLA | Wang J,et al."Dominant kinetic paths on biomolecular binding-folding energy landscape".physical review letters 96.16(2006):文献编号：168101. |
入库方式： OAI收割
来源：长春应用化学研究所
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