Quantifying the kinetic paths of flexible biomolecular recognition
文献类型：期刊论文
| 作者 | Wang J ; Zhang K ; Lu HY ; Wang EK |
| 刊名 | biophysical journal
 |
| 出版日期 | 2006 |
| 卷号 | 91期号:3页码:866-872 |
| 关键词 | ENERGY LANDSCAPE MODEL MOLECULAR RECOGNITION COMBINATORIAL TECHNOLOGIES STATISTICAL-MECHANICS DYNAMICS SIMULATIONS PROTEIN INTERACTIONS INTEGRAL SOLUTIONS FOLDING FUNNELS DRUG DISCOVERY MEMORY KERNELS |
| ISSN号 | 0006-3495 |
| 通讯作者 | wang ek |
| 中文摘要 | biomolecular recognition often involves large conformational changes, sometimes even local unfolding. the identification of kinetic pathways has become a central issue in understanding the nature of binding. a new approach is proposed here to study the dynamics of this binding-folding process through the establishment of a path-integral framework on the underlying energy landscape. the dominant kinetic paths of binding and folding can be determined and quantified. the significant coupling between the binding and folding of biomolecules often exists in many important cellular processes. in this case, the corresponding kinetic paths of binding are shown to be intimately correlated with those of folding and the dynamics becomes quite cooperative. this implies that binding and folding happen concurrently. when the coupling between binding and folding is weak (strong), the kinetic process usually starts with significant folding (binding) first, with the binding (folding) later proceeding to the end. the kinetic rate can be obtained through the contributions from the dominant paths. the rate is shown to have a bell-shaped dependence on temperature in the concentration-saturated regime consistent with experiment. the changes of the kinetics that occur upon changing the parameters of the underlying binding-folding energy landscape are studied. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000239086800012 |
| 公开日期 | 2010-08-17 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/15903]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wang J,Zhang K,Lu HY,et al. Quantifying the kinetic paths of flexible biomolecular recognition[J]. biophysical journal,2006,91(3):866-872. |
| APA | Wang J,Zhang K,Lu HY,&Wang EK.(2006).Quantifying the kinetic paths of flexible biomolecular recognition.biophysical journal,91(3),866-872. |
| MLA | Wang J,et al."Quantifying the kinetic paths of flexible biomolecular recognition".biophysical journal 91.3(2006):866-872. |
入库方式： OAI收割
来源：长春应用化学研究所
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