Kinetic study of paracetamol on prolidase activity in erythrocytes by capillary electrophoresis with Ru(bpy)(3)(2+) electrochemiluminescence detection
文献类型：期刊论文
| 作者 | Yuan JP ; Wei H ; Jin WR ; Yang XR ; Wang EK |
| 刊名 | electrophoresis
 |
| 出版日期 | 2006 |
| 卷号 | 27期号:20页码:4047-4051 |
| ISSN号 | 0173-0835 |
| 关键词 | ANTIINFLAMMATORY DRUGS LIQUID-CHROMATOGRAPHY COLLAGEN-METABOLISM AMINO-ACIDS CANCER RISK HYDROXYPROLINE PROLINE ASPIRIN ACETAMINOPHEN |
| 通讯作者 | wang ek |
| 中文摘要 | we explored the ce with ru(bpy)(3)(2+) electrochemiluminescence detection for the kinetic study of drug-enzyme interaction. effects of four nonsteroidal anti - inflammatory drugs including aspirin, paracetamol, sodium salicylate and phenacetin on prolidase (pld) activity in erythrocytes were investigated. aspirin enhanced pld activity whereas the other three had inhibiting effects. this may reveal their different effects on the collagen biosynthesis and catabolism that influence tumor invasiveness. kinetic study of paracetamol on pld showed that the value of michaelis constant km for pld was 1.23 mm. the mechanism of pld inhibition by paracetamol is noncompetitive inhibition, and the inhibitor constant k-i value obtained in our research was 9.73 x 10(3) mu g/l. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000241916100016 |
| 公开日期 | 2010-08-17 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/16025]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Yuan JP,Wei H,Jin WR,et al. Kinetic study of paracetamol on prolidase activity in erythrocytes by capillary electrophoresis with Ru(bpy)(3)(2+) electrochemiluminescence detection[J]. electrophoresis,2006,27(20):4047-4051. |
| APA | Yuan JP,Wei H,Jin WR,Yang XR,&Wang EK.(2006).Kinetic study of paracetamol on prolidase activity in erythrocytes by capillary electrophoresis with Ru(bpy)(3)(2+) electrochemiluminescence detection.electrophoresis,27(20),4047-4051. |
| MLA | Yuan JP,et al."Kinetic study of paracetamol on prolidase activity in erythrocytes by capillary electrophoresis with Ru(bpy)(3)(2+) electrochemiluminescence detection".electrophoresis 27.20(2006):4047-4051. |
入库方式： OAI收割
来源：长春应用化学研究所
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