Biodegradable amphiphilic triblock copolymer bearing pendant glucose residues: Preparation and specific interaction with Concanavalin A molecules
文献类型：期刊论文
| 作者 | Lu CH ; Chen XS ; Xie ZG ; Lu TC ; Wang X ; Ma J ; Jing XB |
| 刊名 | biomacromolecules
 |
| 出版日期 | 2006 |
| 卷号 | 7期号:6页码:1806-1810 |
| 关键词 | INFLUENZA-VIRUS BLOCK-COPOLYMER POLY(LACTIC ACID-CO-LYSINE) LIGAND RECOGNITION IN-VIVO POLYMERIZATION MICELLES BINDING INHIBITORS GLYCOSIDES |
| ISSN号 | 1525-7797 |
| 通讯作者 | jing xb |
| 中文摘要 | a novel biodegradable amphiphilic block copolymer plgg-peg-plgg bearing pendant glucose residues is successfully prepared by the coupling reaction of 3-(2-aminoethylthio) propyl-r-d-glucopyranoside with the pendant carboxyl groups of plgg-peg-plgg in the presence of n,n'-carbonyldiimidazole. the polymer plgg-peg-plgg, i.e., poly {(lactic acid)-co-[(glycolic acid)-alt-(l-glutamic acid)]}-block-poly(ethylene glycol)-block-poly{( lactic acid)-co-[( glycolic acid)-alt-(l-glutamic acid)]}, is prepared by ring-opening copolymerization of l-lactide (lla) with (3s)-benzoxylcarbonylethylmorpholine-2,5-dione (bemd) in the presence of dihydroxyl peg with molecular weight of 2000 as macroinitiator and sn(oct)(2) as catalyst, and then by catalytic hydrogenation. the glucose-grafted copolymer shows a lower degree of cytotoxicity to ecv-304 cells and improved specific recognition and binding with concanavalin a (con a). therefore, this kind of glucose-grafted copolymer may find biomedical applications. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000238180600018 |
| 公开日期 | 2010-08-17 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/16059]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Lu CH,Chen XS,Xie ZG,et al. Biodegradable amphiphilic triblock copolymer bearing pendant glucose residues: Preparation and specific interaction with Concanavalin A molecules[J]. biomacromolecules,2006,7(6):1806-1810. |
| APA | Lu CH.,Chen XS.,Xie ZG.,Lu TC.,Wang X.,...&Jing XB.(2006).Biodegradable amphiphilic triblock copolymer bearing pendant glucose residues: Preparation and specific interaction with Concanavalin A molecules.biomacromolecules,7(6),1806-1810. |
| MLA | Lu CH,et al."Biodegradable amphiphilic triblock copolymer bearing pendant glucose residues: Preparation and specific interaction with Concanavalin A molecules".biomacromolecules 7.6(2006):1806-1810. |
入库方式： OAI收割
来源：长春应用化学研究所
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