Analysis of nephroloxic and carcinogenic aristolochic acids in Aristolochia plants by capillary electrophoresis with electrochemical detection at a carbon fiber microdisk electrode
文献类型：期刊论文
| 作者 | Zhou XG ; Zheng CY ; Sun JY ; You TY |
| 刊名 | journal of chromatography a
 |
| 出版日期 | 2006 |
| 卷号 | 1109期号:2页码:152-159 |
| 关键词 | ZONE-ELECTROPHORESIS AMPEROMETRIC DETECTION CHINESE HERBS NEPHROPATHY CHROMATOGRAPHY MEDICINES DRUGS |
| ISSN号 | 0021-9673 |
| 通讯作者 | you ty |
| 中文摘要 | aristolochic acids (aas) are the main bioactive ingredients in the most of aristolochia plants, which are used to make dietary supplements, slimming pills and traditional chinese medicines (tcms). excessive ingestion of aas can lead to serious nephropathy. therefore, quantitative analysis and quality control for the plants containing aas is of great importance. in this paper, capillary electrophoresis (ce) with electrochemical detection (ed) at a 33 mu m carbon fiber microdisk electrode (cfe) has been applied to detect aa-i and aa-ii in aristolochia plants. under the optimum conditions: detection potential at 1.20 v, 2.0 x 10(-2) mol l-1 phosphate buffer solution (pbs) (ph 10.0), injection time 25 s at a height of 17 cm and separation voltage at 12.5 kv, the aa-i and aa-ii were baseline separated within 5 min. low detection limits for aa-i and aa-ii were 4.0 x 10(-8) mol l-1 and 1.0 x 10(-7) mol l-1, respectively. wide linear ranges were from 4.0 x 10(-8) mol l-1 to 1.9 x 10(-5) mol l-1 and 1.0 x 10(-7) mol l-1 to 5.0 x 10(-5) mol l-1 for aa-i and aa-ii, respectively. the proposed method has been successfully applied to analyze aas contents in plant extracts. the results indicated that the contents of aas in each part of aristolochia debilis sieb. et zucc. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000236430800007 |
| 公开日期 | 2010-08-17 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/16139]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhou XG,Zheng CY,Sun JY,et al. Analysis of nephroloxic and carcinogenic aristolochic acids in Aristolochia plants by capillary electrophoresis with electrochemical detection at a carbon fiber microdisk electrode[J]. journal of chromatography a,2006,1109(2):152-159. |
| APA | Zhou XG,Zheng CY,Sun JY,&You TY.(2006).Analysis of nephroloxic and carcinogenic aristolochic acids in Aristolochia plants by capillary electrophoresis with electrochemical detection at a carbon fiber microdisk electrode.journal of chromatography a,1109(2),152-159. |
| MLA | Zhou XG,et al."Analysis of nephroloxic and carcinogenic aristolochic acids in Aristolochia plants by capillary electrophoresis with electrochemical detection at a carbon fiber microdisk electrode".journal of chromatography a 1109.2(2006):152-159. |
入库方式： OAI收割
来源：长春应用化学研究所
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