Co-electrospun poly(lactide-co-glycolide), gelatin, and elastin blends for tissue engineering scaffolds
文献类型：期刊论文
| 作者 | Li M ; Mondrinos MJ ; Chen X ; Gandhi MR ; Ko FK ; Lelkes PI |
| 刊名 | journal of biomedical materials research part a
 |
| 出版日期 | 2006 |
| 卷号 | 79a期号:4页码:963-973 |
| 关键词 | IN-VITRO EXTRACELLULAR-MATRIX SMOOTH-MUSCLE COLLAGEN CELL NANOFIBER ADHESION POLYMER PROLIFERATION PROTEIN |
| ISSN号 | 1549-3296 |
| 通讯作者 | lelkes pi |
| 中文摘要 | in this study, we describe composite scaffolds composed of synthetic and natural materials with physicochemical properties suitable for tissue engineering applications. fibrous scaffolds were co-electrospun from a blend of a synthetic biodegradable polymer (poly(lactic-co-glycolic acid), plga, 10% solution) and two natural proteins, gelatin (denatured collagen, 8% solution) and (x-elastin (20% solution) at ratios of 3:1:2 and 2:2:2 (v/v/v). the resulting plga-gelatin-elastin (pge) fibers were homogeneous in appearance with an average diameter of 380 80 mn, which was considerably smaller than fibers made under identical conditions from the starting materials (plga, 780 +/- 200 nm; gelatin, 447 +/- 1.23 nm; elastin, 1060 170 nm). upon hydration, pge fibers swelled to an average fiber diameter of 963 +/- 132 nm, but did not disintegrate. importantly, pge scaffolds were stable in an aqueous environment without crosslinking, and were more elastic than those made of pure elastin fibers. to investigate the cytocompatibility of pge, we cultured h9c2 rat cardiac myoblasts and rat bone marrow stromal cells (bmscs) on fibrous pge scaffolds. we found that myoblasts grew equally as well or slightly better on the scaffolds than on tissue-culture plastic. microscopic evaluation confirmed that myoblasts reached confluence on the scaffold surfaces while simultaneously growing into the scaffolds. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000242360400021 |
| 公开日期 | 2010-08-17 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/16255]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Li M,Mondrinos MJ,Chen X,et al. Co-electrospun poly(lactide-co-glycolide), gelatin, and elastin blends for tissue engineering scaffolds[J]. journal of biomedical materials research part a,2006,79a(4):963-973. |
| APA | Li M,Mondrinos MJ,Chen X,Gandhi MR,Ko FK,&Lelkes PI.(2006).Co-electrospun poly(lactide-co-glycolide), gelatin, and elastin blends for tissue engineering scaffolds.journal of biomedical materials research part a,79a(4),963-973. |
| MLA | Li M,et al."Co-electrospun poly(lactide-co-glycolide), gelatin, and elastin blends for tissue engineering scaffolds".journal of biomedical materials research part a 79a.4(2006):963-973. |
入库方式： OAI收割
来源：长春应用化学研究所
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