Concentration and time dependant behavior of chlorpromazine interaction with supported bilayer lipid membrane
文献类型：期刊论文
| 作者 | Liu H ; Bai HX ; Huang WM ; Du LW ; Yang XR ; Wang EK |
| 刊名 | electrochimica acta
 |
| 出版日期 | 2006 |
| 卷号 | 51期号:12页码:2512-2517 |
| 关键词 | GLASSY-CARBON ELECTRODE PHOSPHOLIPID-MEMBRANES VESICLES PARTITION DRUGS CHOLESTEROL METABOLISM IMIPRAMINE RECEPTORS COMPOSITE |
| ISSN号 | 0013-4686 |
| 通讯作者 | wang ek |
| 中文摘要 | the interaction of chlorpromazine (cpz) with supported bilaver lipid (dipalmitoyphosphatidylcholine) membrane (s-blm) on the glassy carbon electrode (gce) was investigated using cyclic voltammetry and ac impedance spectroscopy. the experimental data, based on the voltammetric response of ru(nh3)(6)(3+) associated with the oxidation of cpz on the electrode, indicated that the interaction of cpz with s-blm was concentration and time dependant. the interaction between them could be divided into three stages by the concentration of cpz: low, middle and high concentration. at the first stage, s-blm was not affected by cpz and the interaction was only a penetration of a small quantity of cpz molecule into s-blm. at the second stage, the defects formed in s-blm due to the penetration of more cpz molecule into s-blm. at the last stage, a high cpz:lipid ratio reached in s-blm, resulting in the solubilization of s-blm. the interaction time had different effect at three stages. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000236019600016 |
| 公开日期 | 2010-08-17 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/16295]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Liu H,Bai HX,Huang WM,et al. Concentration and time dependant behavior of chlorpromazine interaction with supported bilayer lipid membrane[J]. electrochimica acta,2006,51(12):2512-2517. |
| APA | Liu H,Bai HX,Huang WM,Du LW,Yang XR,&Wang EK.(2006).Concentration and time dependant behavior of chlorpromazine interaction with supported bilayer lipid membrane.electrochimica acta,51(12),2512-2517. |
| MLA | Liu H,et al."Concentration and time dependant behavior of chlorpromazine interaction with supported bilayer lipid membrane".electrochimica acta 51.12(2006):2512-2517. |
入库方式： OAI收割
来源：长春应用化学研究所
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