NMR-based metabonomic study on the subacute toxicity of aristolochic acid in rats
文献类型：期刊论文
| 作者 | Zhang XY ; Wu HF ; Liao PQ ; Li XJ ; Ni JZ ; Pei FK |
| 刊名 | food and chemical toxicology
 |
| 出版日期 | 2006 |
| 卷号 | 44期号:7页码:1006-1014 |
| 关键词 | MAGNETIC-RESONANCE-SPECTROSCOPY PATTERN-RECOGNITION H-1-NMR SPECTROSCOPY CHINESE HERBS URINE NEPHROTOXICITY NEPHROPATHY URINALYSIS LIVER CLASSIFICATION |
| ISSN号 | 0278-6915 |
| 通讯作者 | pei fk |
| 中文摘要 | the subacute toxicity of aristolochic acid (aa) was investigated by h-1 nmr spectroscopic and pattern recognition (pr)-based metabonomic methods. model toxins were used to enable comparisons of the urinary profiles from rats treated with known toxicants and aa at various time intervals. urinary h-1 nmr spectra were data-processed and analyzed by pattern recognition method. the result of visual comparison of the spectra showed that aa caused a renal proximal tubular and papillary lesion and a slight hepatic impair. pattern recognition analysis indicated that the renal proximal tubule lesion was the main damage induced by aa, and the renal toxicity induced by aa was a progressive course with the accumulation of dosage by monitoring the toxicological processes from onset, development and part-recovery. these results were also supported by the conventional clinical biochemical parameters. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000238963900009 |
| 公开日期 | 2010-08-17 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/16383]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhang XY,Wu HF,Liao PQ,et al. NMR-based metabonomic study on the subacute toxicity of aristolochic acid in rats[J]. food and chemical toxicology,2006,44(7):1006-1014. |
| APA | Zhang XY,Wu HF,Liao PQ,Li XJ,Ni JZ,&Pei FK.(2006).NMR-based metabonomic study on the subacute toxicity of aristolochic acid in rats.food and chemical toxicology,44(7),1006-1014. |
| MLA | Zhang XY,et al."NMR-based metabonomic study on the subacute toxicity of aristolochic acid in rats".food and chemical toxicology 44.7(2006):1006-1014. |
入库方式： OAI收割
来源：长春应用化学研究所
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